A rhodium complex bearing a chiral bicyclic NHC ligand, [RhCl(3az)(cod)] 4az, was synthesized and fully characterized by X-ray diffraction analysis, high-resolution mass spectrometry, and multinuclear NMR spectroscopy. The electronic and steric properties of NHC ligand 3az were evaluated by IR measurement and X-ray diffraction analysis of dicarbonyl complex [RhCl(3az)(CO) 2 ] 5az, which was prepared by replacing the COD ligand of 4az with CO. The potential of novel complex 4az as a chiral catalyst was investigated in the Rh-catalyzed asymmetric ringopening reaction of oxabenzonorbornadienes with amines, and the corresponding products were afforded in good yields with good enantioselectivities (up to 81% ee).
The treatment of easily accessible o-(1-hydroxy-2alkynyl)-N-tosylanilides 1 with excess manganese(IV) oxide in the presence of substoichiometric tetrabutylammonium iodide (TBAI) in chloroform (or in the absence of TBAI in dimethylformamide, DMF) promoted a sequential oxidation/intramolecular hydroamination to give 4-quinolones 3 and/or (Z)-2-alkylidene-3-oxindoles (Z)-4 in good yields. Possibly, MnO 2 played dual roles as an oxidant and as a Lewis acidic activator of intermediary ynones 2. The product distributions between 3 and (Z)-4 could be controlled by the choice of solvents.
To explore the prevalence and outcomes of the severe acute respiratory syndrome virus-2 Omicron infection in hematologic disease (HD), we performed a prospective observational study on 922 patients with HD and 88 healthcare workers (HCW). We identified 75 and 12 Omicron breakthrough infections in HD and HCW, respectively. In multivariate analysis, older age and use of anti-CD20 antibody within one year were significant independent predictors of breakthrough infection in HD who received two doses of vaccination, but these were not significant for three doses. Of the 75 HD patients infected with Omicron, 66 had mild symptoms and recovered completely, while nine patients required oxygen therapy, three of whom eventually died. In nine patients with longitudinal polymerase chain reaction data available, the five patients who were treated with anti-CD20 antibodies plus bendamustine had prolonged viral shedding. The absolute T-cell subset counts were significantly lower in patients with prolonged viral shedding than in those without. Overall, the symptoms of Omicron infection in HD patients other than those with bendamustine were generally mild and prompt viral clearance was achieved. Even in immunocompromised HD patients, other than those treated with bendamustine, Omicron infection may not require the rigorous infection control as with previous variants.
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