Synthesis of (R)-(+)-Tanikolide Through Stereospecific C-H InsertionReaction of Dichlorocarbene with Optically Active Secondary Alcohol Derivatives. -A stereospecific synthesis of (R)-(+)-tanikolide (XII) is presented. (XII) is a metabolite of the marine cyanobacterium Lyngbya majuscul and exhibits toxic and antifungal activities. The synthesis uses the stereospecific C-H insertion reaction of dichlorocarbene and (I). Two pathways for the synthesis of the key intermediate (VIII) are given. -(ARASAKI, H.; IWATA, M.; MAKIDA, M.; MASAKI*, Y.; Chem. Pharm. Bull. 52 (2004) 7, 848-852; Gifu Pharm. Univ., Mitahora, Gifu 502, Japan; Eng.) -M. Bohle 51-184
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