Our study provides strong evidence that adult height is a risk factor for breast cancer in women and certain genetic factors and biological pathways affecting adult height have an important role in the etiology of breast cancer.

Background: Accidental or suicidal poisoning with yellow phosphorus or metal phosphides (YPMP) such as aluminum (AlP) zinc phosphide (Zn 3 P 2) commonly causes acute liver failure (ALF) and cardiotoxicity. These are used as household, agricultural, and industrial rodenticides and in production of ammunitions, firecrackers, and fertilizers. In absence of a clinically available laboratory test for diagnosis or toxin measurement or an antidote, managing their poisoning is challenging even at a tertiary-care center with a dedicated liver intensive care unit (LICU) and liver transplant facility. Methods: Patients with YPMP-related ALF were monitored using standardized clinical, hemodynamic, biochemical, metabolic, neurological, electrocardiography (ECG), and sequential organ failure assessment (SOFA) score and managed using uniform intensive care, treatment, and transplant protocols in LICU. Sociodemographic characteristics, clinical and biochemical parameters, and scores were summarized and compared between 3 groups i.e. spontaneous survivors, transplanted patients, and non-survivors. Predictors of spontaneous survival and the need for liver transplant are also evaluated. Results: Nineteen patients with YPMP-related ALF were about 32 years old (63.2% females) and presented to us at a median of 3 (0-10) days after poisoning. YPMP-related cardiotoxicity was rapidly progressive and fatal, whereas liver transplant was therapeutic for ALF. Spontaneous survivors had lower-dose ingestion (<17.5 g), absence of cardiotoxicity, < grade 3 hepatic encephalopathy (HE), lactate < 5.8, SOFA score < 14.5, and increase in SOFA score by < 5.5. Patients with renal failure need for continuous veno-venous hemodiafiltration (CVVHDF) and King College criteria positivity on account of prothrombin time and international normalized ratio (PT-INR) > 6.5 had higher mortality risk. Patients undergoing liver transplant and with spontaneous recovery required longer intensive care unit and hospital stay. At median follow-up of 3.4 (2.6-5.5) years, all spontaneous survivors and transplanted patients are well with normal liver function. Conclusions: Early transfer to a specialized center, preemptive close monitoring, and intensive care and organ support with ventilation, CVVHDF, plasmapheresis, and others may maximize their chances of spontaneous recovery, allowing accurate prognostication and a timely liver transplant. (J CLIN EXP HEPATOL xxxx;xxx:xxx)

The study of biphasic soft tissues contact is fundamental to understanding the biomechanical behavior of human diarthrodial joints. However, to date, few biphasic finite element contact analysis for 3D physiological geometries under finite deformation has been developed. The objective of this paper is to develop a hyperelastic biphasic contact implementation for finite deformation and sliding problem. An augmented Lagrangian method was used to enforce the continuity of contact traction and fluid pressure across the contact interface. The finite element implementation was based on a general purpose software, COMSOL Multiphysics. The accuracy of the implementation is verified using example problems, for which solutions are available by alternative analyses. The implementation was proven to be robust and able to handle finite deformation and sliding.

It has been 60 years since the fi surgery was performed yet questions concernin and implant design is most effective for specific remain unanswered. There is a need for a fas solution to test implants for their efficacy un conditions.The primary objective of this project is to esta design space for developing meniscal impla describes the process of building a 3-D mod volumetric MRI data using commercially availa and model building software. The model, when a variety of physiological conditions using formulation developed for 3-D contact of bipha verified against experimental data in whole in-vi

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