Surface coating of
plasmonic nanoparticles is of huge importance
to suppress fluorescence quenching in plasmon-enhanced fluorescence
sensing. Herein, a one-pot method for synthesizing polymer-coated
silver nanoparticles was developed using a functional polymer conjugated
with disulfide-containing anchoring groups. The disulfides played
a crucial role in covalently bonding polymers to the surface of the
silver nanoparticles. The covalent bond enabled the polymer layer
to form a long-term stable coating on the silver nanoparticles. The
polymer layer coated was adequately thin to efficiently achieve plasmonic
enhancement of fluorescence and also thick enough to effectively suppress
quenching of fluorescence, achieving a huge net enhancement of fluorescence.
The polymer-coated plasmonic nanoparticles are a promising platform
for demonstrating highly sensitive biosensing for medical diagnostics.
We developed novel polymer layers to facilely coat plasmonic metal nanoparticles to obtain strong net fluorescence intensity and employed the polymer-coated silver nanoparticles for highly sensitive biosensing based on plasmon-enhanced fluorescence.
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