Aspects of NAFLD including steatohepatitis improved significantly with massive weight loss at 2 years after RYGB surgery. No patient in this series had progression of hepatic fibrosis.
The surface structure of mesoporous silica crystals FSM-16 with a narrowly distributed pore size has been studied by FTIR, measurement of SiOH number and adsorption of N, and H,O. IR spectra of FSM-16 outgassed at temperatures above 170°C showed a sharp band at 3740 cm-' due to free SiOH and a broad shoulder at 3600-3500 cm-' due to hydrogen-bonded SiOH. The SiOH number, determined by a weight-loss method, amounted to 3.3 groups nrn-,, which is less than that of mesoporous silica gels. The amount of H,O adsorbed on FSM-16 decreased with calcination above 800"C, owing to the dehydroxylation of SiOH. On treating with alcohol, the number of free SiOH decreased, leading to a decrease in H,O adsorption. The crystallinity of FSM-16 was lowered by pressing. With increasing pressure the specific surface area decreased and the SiOH number increased, up to 9.5 groups nrn-,.
Serious malnutrition was unusual but not exceedingly rare in this series. Exogenous precipitating factors were clearly identified in 63.6% of the patients. Careful clinical and nutritional follow-up is recommended to prevent these uncommon but potentially dangerous complications.
1) Nonalcoholic steatosis, steatohepatitis and cirrhosis were identified in substantial numbers of morbidly obese patients; 2) Concentration of hydroperoxides was increased in steatohepatitis, consistent with a pathogenetic role for oxidative stress in this condition.
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