Influenza viruses are common respiratory pathogens in humans and can cause serious infection that leads to the development of pneumonia. In this study, the clinical and laboratory features of 36 patients from Turkey who are hospitalized in intensive care unit due to pandemic influenza A (H1N1) associated pneumonia and respiratory failure were retrospectively evaluated. The most common symptoms were cough and fever. Consolidation (36.1 %) and interstitial changes (30.6 %) were the most frequently identified findings on chest radiographs at the time of admission. Six of the patients (16.7 %) died. Mortality occurred in 3 of 13 patients (23.1 %) with underlying disease, whilst it occurred in only 3 of 23 patients (13 %) who were previously healthy. Mortality was found to be significantly associated only with an elevated lactate dehydrogenase level. A significant relationship was determined only between the presence of lymphopenia and acute respiratory distress syndrome and the need for intensive care treatment. The average time elapsed from the onset of the symptoms until admission was 8.67 ± 2.87 days for the patients died, and 6.0 ± 3.8 days for the patients survived.
In certain types of cancer, increased serum protease inhibitor levels were identified and clues showing that, serum levels of protease inhibitor could be used in the assessment of prognosis and dissemination of tumor were obtained. We aimed to reveal whether serum alpha-1-antitrypsin (AAT) and alpha-2-macroglobulin (AMG) levels of patients with lung cancer are related with histological type, clinical stage, and advance of cancer. The patients enrolled in the study were the ones with a histopathologic diagnosis of primary lung cancer and they were not administered any treatment before. Levels of serum AAT and AMG were analyzed at the moment of diagnosis. A total of 47 patients were enrolled in the study -42 males and 5 females. The average age was 58.9. Tumor cell type was non-small cell lung carcinoma (NSCLC) in 36 and small cell lung carcinoma in 11 patients. There was a negative correlation between serum AAT level and age (p= 0.21 r=-0.339). No correlation was identified between serum AMG level and age (p= 0.138 r= 0.222). There was no significant relation between histological types of lung cancer and serums AAT and AMG (p= 0.807, p= 0.411 respectively). AAT and AMG levels were not different in limited and extensive small cell lung carcinoma (p= 0.201 and p= 0.465). AAT and AMG levels based on stages were not found to be different in NSCLC (p= 0.646 and p=0.650). AAT and AMG levels did not vary based on distant metastasis or local spread in NSCLC (p= 0.371 and p= 0.676). Serum alpha-1-antitrypsin and alpha-2-macroglobulin levels in patients with lung cancer do not vary based on histological types, stage of the disease, local, distant and lymphatic spread of the tumor.Keywords: Lung cancer, Alpha-1-antitrypsin, Alpha-2-macroglobulin, Histology, Stage, Metastasis ÖZET Akciğer Kanserinde Serum Alfa-1-Antitripsin ve Alfa-2-Makroglobulin Düzeyleri ile Tümor Histolojisi veya Yaygınlığı İlişkili mi?Bazı kanser tiplerinde artmış serum proteaz inhibitor düzeyleri saptanmış ve serum proteaz inhibitör düzeylerinin tümörün yaygınlığında, prognozun değerlendirilmesinde kullanılabileceğine dair ipuçları elde edilmiştir. Akciğer kanserli hastalarda serum alfa-1-antitripsin (AAT) ve alfa-2-makroglobulin (AMG) düzeyleri ile kanserin histolojik tipi, klinik evresi ve yaygınlığı arasında ilişki olup olmadığını ortaya koymayı amaçladık. Histopatolojik olarak primer akciğer kanseri tanısı konulan, herhangi bir tedavi uygulanmamış hastalar çalışmaya alındı. Teşhis anında serum AAT ve AMG düzeyleri incelendi. Çalışmaya 42 erkek ve 5 kadın, toplam 47 hasta alındı. Yaş ortalaması 58,9 yıl idi. Tümör hücre tipi 36 hastada küçük hücreli dışı akciğer karsinomu (KHDAK) ve 11 hastada küçük hücreli akciğer karsinomu idi. Serum AAT düzeyi ve yaş arasında negatif korelasyon var idi (p= 0.21 r=-0,339). Serum AMG düzeyi ve yaş arasında korelasyon saptanmadı (p= 0.138 r=0.222). Akciğer kanserinin histolojik tipleri ile serum AAT ve AMG arasında anlamlı ilişki saptanmadı (sırasıyla p= 0.807, p= 0,411). Küçük hücreli akciğer karsinomunda s...
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