Oral infections are usually caused by poly bacterial. Approximately 60% of oral infections are caused by joint aerobic and anaerobic bacteria; 35% caused by anaerobic bacteria and 5% due to aerobic bacteria. When aerobic bacteria are involved, Gram positive aerobic cocci are the most common aerobic species involved in oral cavity infection (e.g., Streptococci (e.g., Streptococci "species" (spp), Staphylococci spp). In cases of anaerobic and/ or mixed infection Streptococci spp, Peptostreptococci spp and gram-negative anaerobic bacilli (Prevotella spp, Porphyromonas spp, Bacteroides spp, and Fusobacterium spp) are involved. [1,2].It has been hypothesized that synergism between more than one type of bacteria in a particular infection plays a key role in their pathogenicity. Accordingly the target of the antimicrobial control Local application of natural antimicrobial products on oral infection site can be considered useful alternative to common antibiotics. Cinnamomum zeylanicum (C.Z) has been found to be effective against both types of bacterial (Gram-negative and Gram-positive bacterial), which play roles in human infections responsible for human infectious diseases. This study aimed to assess the efficacy of (C.Z) antibacterial activity on isolates from orofacial infections. The antibacterial activity of crude (C.Z) ethanol extracts on four types of oro-facial infection microorganisms was studied; ciprofloxacin an antibiotic was used as positive control. The Results showed All four bacterial isolates (Staphylococcus aureus, Escherichia coli, Peptococcus and S. Mutans) were sensitive towards the ethanol extract of Cinnamomum. However, the maximum antimicrobial activity has been shown against Staphylococcus aureus. This study is the first of a series of studies to produce Cinnamon extract for local control of oral facial infections. Conclusion and clinical significance is Crude (C.Z) ethanol extract effective against aerobic, anaerobic, gram positive and gram negative oral pathogens. The extract might be employed to make an effective spray or ointment for orofacial infection.for such infection will be the synergism between key offending organisms and there is no need for specific medication for every involved bacteria in the infection process [1,3].Recently there has been more focus natural materials, more specifically aromatic plants with wide biological medicinal applications [4][5][6]. Among them is Cinnamon, which is a spice, commonly used in food. The aroma its oil has makes it useful in food industry [7]. One of Cinnamon species is C. zeylanicum. C. zeylanicum contains eugenol [8][9][10], in addition to it Antimicrobial property of C. zeylaincum is attributed to the presence of cinnamyl acetate, methoxy cinnamaldehyde (MOCA) and other volatile compounds [11,12]. Among cinnamon extracts, essential oils and components have been identified for their activity against
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