This study aims to identify the most important parameters in the Physiologically-Based Pharmacokinetic (PBPK) model of Peptide Receptor Radionuclide Therapy (PRRT). By knowing the size of the contribution of physiological parameters to the PBPK model, it can reduce the variability of the absorbed dose (AD) in organs at risk, such as the kidney and tumor between individuals. The small variability has the potential to increase the accuracy of planning individual radionuclide therapy treatments. This study uses the extended Fourier Amplitude Sensitivity Test (eFAST) Global Sensitivity Analysis method, the best variance-based global method in analyzing the PBPK model. A whole-body PBPK model that has been developed for treatment planning in PRRT therapy for meningioma patients (n = 7). The parameters of interest analyzed were organ receptor densities Rdens, organ flows f, organ release rates, and peptide binding rate. AD as the desired output from the eFAST algorithm by calculating Si
and STi
from each AD Kidney and AD Tumor. All parameters of interest are converted into the lognormal distribution. The sampling strategy based on eFAST sampling, the interference factor is equal to 4. To see the convergence of the convergence value of Si
and STi
, a simulation was performed with a total evaluation of 129, 257, 513, 1025, 2049, 4097, and 8193. The results of the simulation, inter-individual variability of tumor AD (coefficient of variation CV up to CV = 73%) was higher than that organ at risk (e.g. kidneys CV around 22%). Based on GSA analysis, the most important parameter determined the AD of tumors, tumors receptor density (Si
= 0.8, S
Ti
= 0.93), kidneys AD was kidneys receptor density (Si
= 0.66, STi
= 0.71). After validating Si
by fixing every parameter considered important, the results can reduce the CV of the kidney AD from 22% to 1%, with a decrease in CV presentation of around 95%. CV AD tumor 1 was reduced by 68% from CV 44% to 14%, and CV in tumor AD 2 from 72% to 17% with a reduced CV presentation of about 77%. It was concluded that receptor measurement is important because it can improve the accuracy of radionuclide therapy treatment.
Illegal drugs are solid or liquid substances, gases that cause physical and psychological changes in the body, almost all drugs affect the central nervous system, drugs act on the brain and can affect anesthesia, view the emergence of side effects and the high persistence to use illegal drugs without being prescribed by a doctor and can cause drug addiction or addiction. Some factors cause drug users, namely environmental factors, family factors and social factors, and 179 drug users in Bulukumba class IIA prisons.The purpose of this study: is to know the factors of the use of illegal drugs in class IIA Bulukumba. The research design used was a qualitative study with a phenomenological approach through in-depth interview techniques. Data was collected in the form of records and results of interviews. Respondents in this study amounted to 6 people using illegal drugs who were selected by purposive sampling. In this study, several theme analysis results were obtained, namely (1) first try (2) the influence of family factors (3) the influence of social factors. Conclusion: Drug users occur as a result of the first try factor, high curiosity, and friend invitations, drug users occur due to family factors, and drug users occur as a result of free sex.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.