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Background The use of remdesivir has demonstrated a significant reduction in the time to recovery in patients with COVID-19. However, the impact on mortality is still controversial. Therefore, it is necessary to evaluate whether there is a specific subgroup of patients in whom an active antiviral therapy also reduces the mortality. Methods Patients admitted for >48 h in our hospital for a SARS-CoV-2 confirmed or suspected infection from February 2020 to February 2021 were retrospectively analysed. The primary outcome of the study was mortality at 30 days. Univariate and multivariate analyses were performed to identify predictors of mortality. Results In total, 2607 patients (438 receiving remdesivir and 2169 not) were included with a median (IQR) age of 65 (54–77) years and 58% were male. Four hundred and seventy-six were admitted to the ICU (18.3%) and 264 required invasive mechanical ventilation (10.1%). The global 30 day mortality rate was 10.7%. Pre-admission symptom duration of 4–6 days and ≤3 days was associated with a 1.5- and 2.5-fold increase in the mortality rate, respectively, in comparison with >6 days and treatment with remdesivir was independently associated with a lower mortality rate (OR = 0.382, 95% CI = 0.218–0.671). The analysis showed that the major difference was among patients with shorter pre-admission symptom duration (<6 days). Conclusions Patients with ≤3 days and 4–6 days from symptom onset to admission are associated with a 2.5- and 1.5-fold higher risk of death, respectively. Remdesivir was associated with 62% reduced odds of death versus standard-of-care and its survival benefit increased with shorter duration of symptoms.

Objective: Intimate partner violence (IPV) is a serious public health concern that affects many Latinx couples. The present study conducted a systematic review and meta-analysis to quantitatively assess acculturation as a predictor of IPV among Latinxs and subgroup analyses to evaluate the effect size by gender and type of acculturation measure. Method: The meta-analysis implemented the preferred reporting items for systematic reviews and meta-analyses guidelines to retrieve studies assessing the relationship between acculturation and intimate partner victimization among foreign-born and U.S.-born Latinx adults. A fixed effects model (FEM) and a random effects model (REM) were employed. Additional subgroup analyses examined the strength of the relationship by gender and type of acculturation measure. Results: The meta-analysis included 27 independent effect sizes across 21 studies. An REM yielded a weighted average correlation of .11 (95% confidence interval [.02, .20]). The strength of the correlation differed by scale and ranged from −.003 to .47. For both men and women, higher acculturation was associated with increased IPV. Conclusions: Our results yielded three important findings: (1) the overall effect of acculturation on IPV is relatively small, (2) acculturation differentially influences male-to-female and female-to-male partner violence, and (3) the strength of the correlation between acculturation and IPV differs by scale. This body of work provides evidence for the effect of acculturation on IPV, with potential implications for interventions targeting Latinxs.

Research on health among Latinos often focuses on acculturation processes and the associated stressors that influence drinking behavior. Given the common use of acculturation measures and the state of the knowledge on alcohol-related health among Latino populations, the current analyses tested the efficacy of acculturation measures to predict various indicators of alcohol consumption. Specifically, this quantitative review assessed the predictive utility of acculturation on alcohol consumption behaviors (frequency, volume, and quantity). Two main analyses were conducted-a p-curve analysis and a meta-analysis of the observed associations between acculturation and drinking behavior. Results demonstrated that current measures of acculturation are a statistically significant predictor of alcohol use (Z = -20.75, p < 0.0001). The meta-analysis included a cumulative sample size of 29,589 Latino participants across 31 studies. A random-effects model yielded a weighted average correlation of 0.16 (95% confidence interval = 0.12, 0.19). Additional subgroup analyses examined the effects of gender and using different scales to measure acculturation. Altogether, results demonstrated that acculturation is a useful predictor of alcohol use. In addition, the meta-analysis revealed that a small positive correlation exists between acculturation and alcohol use in Latinos with a between-study variance of only 1.5% (τ = 0.015). Our analyses reveal that the association between current measures of acculturation and alcohol use is relatively small.