Purpose: To investigate whether myricetin ameliorates lipopolysaccharide (LPS)-induced acute lung inflammation (ALI) in a rat model, and to elucidate the probable molecular mechanism of action involved.Methods: Myricetin (10, 20 and 40 mg/kg)
was administered to rats 30 min after intratracheally administering LPS (5 mg/kg). BALF protein concentration, lung wet-to-dry weight ratio, myeloperoxidase (MPO) activity, cytokine production and migration of inflammatory cells were evaluated.
Results: Myricetin significantly (p ≤ 0.05) attenuated lung inflammation as evident from the decreased wet-to-dry weight ratio of lungs, concentration of protein in the BALF
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