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These findings provided preliminary evidence for GM changes in the striatum and different structural covariance patterns in patients with FD. The current results might expand our understanding of the pathophysiology of FD.

Purpose of Review This review aims at outlining alpha-2-macroglobulin (A2M) injection, a novel non-operation strategy which could delay the process of osteoarthritis (OA). Meanwhile, some burning issues concerning “experimental” and “applied” are also indicated in this review. Recent Findings Many researchers have found that the alpha-2-macroglobulin, a sort of broad-spectrum proteinase inhibitor, presents remarkable inhibitive effect on intra-articular inflammation. Additionally, results of animal experiments prove that the A2M can postpone cartilage degeneration. Some treatments, such as hyaluronic acid (HA), which have been applied clinically for many years proved not to be as effective; thus, the advantage of A2M is presented. Summary A2M promises to be a new strategy of non-operative treatment of OA for its excellent anti-inflammation effect and biosafety. Better improved pharmaceutical preparations and treatment strategies shall be developed with the in-depth research.

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Different from microwave radar, laser radar could be more sensitive to the micro-Doppler (m-D) effect due to its wave length. This limits the application of conventional methods, such as time–frequency based approach, since the processing needs a receiver with much higher sampling frequency than microwave radar. In this paper, a micro-Doppler feature extraction algorithm is proposed for the inverse synthetic aperture imaging laser radar (ISAIL). Singular-spectrum analysis (SSA) is employed for separation and reconstruction of the micro-Doppler and rigid body signal. Clear ISAIL image is obtained by minimum entropy criteria after echo signal decomposition. After theoretical derivation, the computation efficiency and ability of the proposed method is proved by the results of simulation and real data of An-26.