Heart attacks are a highly prevalent and often life-threatening disease in modern society. Numerous studies have now shown that many biomarkers in blood have been identified as markers for the detection of heart attack and some are widely used in clinical practice, including protein-based and nucleic acid-based markers. With further research into the pathogenesis of heart attacks, new, simpler and earlier biomarkers have been identified. In this paper, we present a comprehensive review of the role of protein, nucleic acid and cytokine markers in the diagnosis of heart attack based on the pathogenesis of heart attack. It is expected that the discovery of markers based on heart attack will help in the clinical diagnosis of acute heart attack and provide some data to support the early detection and treatment of patients with sudden acute heart attack, thus improving the quality of life and long-term outcome of patients.