In searching for various kinds of painkillers and comparing the pharmaceutical effects of them, morphine and M6G, metadon, sufentanil are the most common and attractive among all the painkillers. The content below would mainly introduce the mechanism of opioid painkillers, which include the receptors and process of how opioids work, and these four drugs in their sources, effective dose, therapeutic effects and side effects. Except the same point of reliving pain, these drugs have different specialties and contraindication, so study them respectively and analogy them in different fields is essential to distinguish them and use them in different situations. Although the data from those literature is very convinced, there are still more studies need to be done to figure out more advanced drugs in the future.
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