Base-pairing is stable
under physiological temperature but broken
by heating, which is the basic mechanism for nucleic acid amplification
in biology. In this manuscript, a simple controlled-drug-release system
was prepared on the basis of this rule and its in vivo activity was
studied. Poly adenine (poly A), the tail of the synthesized RNA chain,
was exploited as gatekeeper of thymine (T)-modified mesoporous silica
nanoparticles (MSN-T) based on the simple A-T base-pairing rules.
The gate keeper maintains stability to avoid drug (chemotherapy and
photothermal therapy drugs) release during the delivery process but
is effectively removed by a photothermal effect to trigger drug release
at the tumor tissue by near-infrared (NIR) laser irradiation. In vitro
and in vivo experiments indicated that the prepared nanomedicine could
effectively suppress tumor growth and activate antitumor immunity.
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