The present study
was designed to develop multifunctional zinc
oxide-encapsulated Eudragit FS30D (ZnO/EFS) nanohybrid structures
as a biodegradable drug delivery system and as a promising successful
carrier for targeting sites. The solvent evaporation method was used
to fabricate the ZnO/EFS nanohybrids and the size, shape, stability,
and antioxidant activity were characterized using transmission electron
microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction
(XRD), Fourier transform infrared (FTIR) spectroscopy, dynamic light
scattering (DLS), thermogravimetric analysis (TGA), and an antioxidant
(1,1-diphenyl-2-picrylhydrazyl (DPPH)). Zinc oxide-encapsulated Eudragit
FS30D (ZnO/EFS) nanohybrid structures consisted of irregularly shaped,
297.65 nm-sized ZnO/EFS microcapsule, enduring thermal stability from
251.17 to 385.67 °C. Nano-ZnO was encapsulated in EFS through
the formation of hydrogen bonds, and the average encapsulation efficiency
for nano-ZnO was determined to be 96.12%. In vitro intestinal-targeted
drug release assay provided 91.86% with free nano-ZnO, only 9.5% in
acidified ZnO/EFS nanohybrid structure but the rate ZnO/EFS nanohybrids
reached 93.11% in succus entericus resultantly modified nano-ZnO was
proven proficient intestinal-specific delivery system. The stability
of the ZnO/EFS nanohybrid structures was confirmed using ζ-potential
and antioxidant activity analysis. Hence, the EFS nanoencapsulation
strategy of ZnO provided a stable, nontoxic, and pharmacokinetically
active intestine-specific system that can become the best choice for
an effective oral feed additive in future.
We demonstrate a successful design of an adenine-based BioMOF for highly sensitive formaldehyde recognition without the interference of other VOCs by utilizing its reactivity on Watson–Crick sites and MOF compartmentalization.
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