Aim: Breast cancers at different stages have tremendous differences on both phenotypic and molecular patterns. The developmental stage is an essential factor in the clinical decision of treatment plans, but was usually formulated as a classification problem, which ignored the consecutive relationships among them. Materials & methods: This study proposed a regression-based procedure to detect the stage biomarkers of breast cancers. Biomarkers were detected by the Lasso and Ridge algorithms. Results & conclusion: A collaboration duet of Lasso and Ridge regression algorithms achieved the best performances, with classification accuracy (Acc) equal to 0.8294 and regression goodness-of-fit (R2) equal to 0.7810. The 265 biomarker genes were enriched with the signal peptide-based secretion function with the Bonferroni-corrected p-value equal to 6.9408e-3 and false discovery rate (FDR) equal to 1.1614e-2.
In order to demonstrate the modulation of terahertz wave propagation in atmospheric pressure microplasmas, in this work, the band structure and the transmission characteristics of a onedimensional collisional microplasma photonic crystal are investigated, using the transfer matrix method. For a lattice constant of 150 μm and a plasma width of 100 μm, three stopbands of microplasma photonic crystal are observed, in a frequency range of 0.1-5 THz. Firstly, an increase in gas pressure leads to a decrease in the central frequency of the stopband. When the gas pressure increases from 50.5 kPa to 202 kPa, the transmission coefficient of the THz wave first increases and then decreases at high frequency, where the wave frequency is much greater than both the plasma frequency and the collision frequency. Secondly, it is interesting to find that the central frequency and the bandwidth of the first THz stopband remain almost unchanged for electron densities of less than 10 15 cm -3 , increasing significantly when the electron density increases up to 10 16 cm -3 . A central frequency shift of 110 GHz, and a bandgap broadening of 200 GHz in the first stopband are observed. In addition, an atmospheric pressure microplasma with the electron density of 1×10 15 -6×10 15 cm -3 is recommended for the modulation of THz wave propagation by plasma photonic crystals.
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