A series
of benzimidazo[1,2-c]quinazolines have
been synthesized via phenyliodine(III) diacetate (PIDA)-mediated intramolecular
C–H bond cycloamination reaction. This method results in a
direct oxidative C–N bond formation in a complex molecule by
using a metal-free protocol. A plausible reaction mechanism was described
on the basis of the experiments. Some new compounds were evaluated
for their antitumor activity against HUH 7 and SK-HEP-1 hepatocarcinoma
cell line. Among the compounds screened, 4m was found
to be the most active compound against HUH 7.
d-Glucosamine has been studied for C–N and C–S bond formations via cross-coupling reactions of nitrogen and sulfur nucleophiles with both aryl iodides and bromides.
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