SummaryThis trial aimed to compare the maternal and neonatal effects of remifentanil given by patient-controlled analgesia (PCA) or continuous infusion for labour analgesia. Patient controlled analgesia was administered using increasing stepwise boluses from 0.1 to 0.4 lg.kg À1 (0.1 lg.kg À1 increment, 2 min lockout, n = 30 Several lines of evidence have shown that intravenous remifentanil is effective for pain relief in parturients who received labour analgesia because of its particular pharmacokinetic characteristics [1][2][3][4][5][6]. Remifentanil has a quick onset time, rapid degradation by plasma and tissue esterase to inactive metabolites (terminal elimination half-life of 9.5 min), a short t 1/2 Keo (time needed for the effect compartment concentration to reach 50% of plasma concentration of 1.3 min) and a constant context sensitive half-life of 3.2 min [7][8][9]. However, labour analgesia with intravenous remifentanil has been reported to be associated with adverse reactions including maternal oversedation and oxygen desaturation as well as fetal heart rate decelerations 236 Anaesthesia

Ondansetron preloading combined with crystalloid infusion significantly reduced hypotension and nausea, while improving acid-base status, as well as reducing vasoconstrictor use.

This study aims to evaluate the efficacy and safety of oxycodone hydrochloride in treating postoperative uterine contraction pain in dysmenorrhea patients undergoing negative pressure aspiration.This study is a multicenter randomized controlled clinical trial. Two hundred patients with history of moderate or severe dysmenorrhea for negative pressure aspiration were divided into 4 groups evenly (n = 50): the control group (group P, isotonic saline), the low-dose oxycodone group (group O1), the medium-dose oxycodone group (group O2), and the high-dose oxycodone group (group O 3 ). All the 4 groups were followed by slow (45-60 seconds) static push of propofol until eyelash reflex disappeared (a maximum dose of 2.5 mg/kg). Additional propofol (0.6-1 mg/kg) was added if body movement occurred during operation.The postoperative VAS scores in different groups showed that there was no statistical difference between groups P and O1, while there were statistical differences when groups O2 and O3 were compared with group P (P < .01), and when group O3 compared with O1 (P < .01). Furthermore, there was no significant differences in HR and BP among the 4 groups, but the intraoperative respiratory frequency in groups O1, O2, and O3 was significantly higher than in group P (P < .01). The SPO 2 after operation in groups O2 and O3 was higher than in group P (P < .05). There was a significant difference in the VAS ≥ 4 between group O2 or O3 and Group P (P < .01). The incidence of respiratory depression in P group was significantly higher than in O1, O2, and O3 groups (P < .01). The dilatation time and the number of dilatation bar used in group O3 is lower than that of group P and group O1 (P < .01). The difficulty of dilatation in group P was 26% as assessed by clinicians, with significant differences with groups O1, O2, and O3 (P < .01). Conclusion:Oxycodone hydrochloride injection could be safely and effectively applied to negative pressure aspiration, and a 0.08 mg/kg dose could significantly reduce postoperative uterine contraction pain of patients with dysmenorrhea.

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