Background: Golgi-resident GlcNAc-1-phosphotransferase is the key enzyme for biosynthesis of mannose 6-phosphate recognition marker. Results: Identification of a combinatorial ER export motif in the N-and C-terminal cytosolic domains of the GlcNAc-1-phosphotransferase ␣/-subunit precursor protein.Conclusion: COPII-dependent ER export of the phosphotransferase precursor is mediated by dileucine/dibasic sorting motifs. Significance: Novel insights into ER sorting of type III membrane proteins are discussed.
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