Background Progressive familial intrahepatic cholestasis is a heterogeneous group of disorders, leading to intrahepatic cholestasis, with the possibility of chronic liver failure and biliary cirrhosis. Oligodontia is either the manifestation of a specific syndrome or is non-syndromic. To the best of our knowledge, this is the first case report of type 3 progressive familial intrahepatic cholestasis and concurrent oligodontia, craniosynostosis, dens in dente, taurodontism, and delayed permanent dentition in the medical and dental literature. Case presentation We present the dental and medical histories and comprehensive dental management of a girl with type 3 progressive familial intrahepatic cholestasis and several dental anomalies, who was referred to a dental clinic due to severe dental caries and pain. Conclusion Our findings suggest that PFIC with manifestations as oligodontia, craniosynostosis, dens in dente, taurodontism, and delayed permanent dentition, might indicate an unknown syndrome; otherwise, the craniofacial anomalies are the manifestations of an independent disease coinciding with PFIC. Moreover, our case is a good example of the importance of timely medical and dental care in confining further health-related complications. The patient was able to ingest without any pain or discomfort after receiving proper dental management.
Introduction: Odontomas are the most common odontogenic tumors. These lesions are usually considered a hamartoma than a neoplasm. Unlike normal tooth morphology, tissue arrangement is irregular in these lesions. Odontoma has self-limiting and slow growth, and if left untreated, its size will not increase over time. Most of these lesions are clinically asymptomatic and are detected on routine radiographs prepared for other purposes. Odontomas usually are located pericoronally and cause tooth eruption disorders such as the lack of permanent teeth or retention of deciduous teeth. In some cases, an odontoma can cause swelling and expansion of the jaw. The purpose of the current report is presenting an unusual complex odontoma in a 10-year-old boy, which was closely related to the roots of tooth #30. Odontomas are usually located pericoronally and near the roots of adjacent teeth, separated by a septum of bone. There are a few reported cases such as the current case, with fusion to the tooth structure. There was slight intraoral swelling and tenderness in the affected region. Unlike most reported cases, tooth eruption disturbance was not observed. Extreme proximity of odontoma and the roots of tooth were detected in Cone-beam Computed Tomography examination. Separative bone septum and the sharp outline of the tooth roots did not detected. The lesion and the related tooth were removed by surgical treatment, and the patient was followed for 2 years.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus originates from Wuhan, China; it has spread around the world. According to studies, the results of the SARS-CoV-2 test have been reported positive for some pregnant women. However, not much is known about the effect of this virus on pregnancy and the outcome of baby. The aim of this review study was to evaluate the molecular and diagnostic approach in evaluating the effect of coronavirus disease 2019 (COVID-19) on pregnancy loss. The entry of COVID-19 virus into the pregnant mother’s body through various channels, such as the angiotensin-converting enzyme receptor (ACE2) affects immune and coagulation systems and hormone levels. These changes include D-Dimer, platelets and antithrombin III (AT-III) raises and protein C (PC) decrement and also elevated levels of pro-inflammatory cytokines, including IL-6, followed by disruption of various signaling pathways such as JAK / STAT and PI3K. Additionally, decreased expression of cyclooxygenase 1 (COX1) and prostaglandin E2 (PGE2) and hormones such as progesterone were observed. These changes ultimately lead to serious pregnancy risks, including miscarriage. Therefore, identifying pathways by which COVID-19 impairs immune and coagulation systems of pregnant women can be a way to design abortion preventive strategies.
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