A simple and facile approach has been applied for the synthesis of molybdenum disulfide nanosheets (MNs). Molybdenum disulfide nanosheets were prepared by mix‐solvent reflux exfoliation technique of bulk MoS2 with ethanol/water as the solvent. In this paper, a novel nano sorbent is reported for the surface grafting of poly [N‐Vinyl caprolactam‐co‐Vinyl Acetate] copolymer onto molybdenum disulfide nanosheets. The MNs@ p (NVCL‐co‐VAc) was modified by 3, 4‐diaminobenzoic acid (DABA) to enhance its adsorption capacity. The ability of MNs@ p (NVCL‐co‐VAc)‐DABA was estimated as a nanocarrier for the delivery of Imatinib Mesylate (IM) as an anticancer drug. The polymer grafted MNs@ p (NVCL‐co‐VAc)‐DABA was characterized by using field emission scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, elemental analysis, and X‐ray powder diffraction. The effect of the experimental parameters, such as pH, contact time, and the temperature was evaluated. In vitro controlled drug release and phototherapy under near‐infrared (NIR) light irradiation are also discussed. In vitro release of IM from IM/MNs@ p (NVCL‐co‐VAc)‐DABA nanocarriers in the simulated blood fluid (pH = 7.4) shown that the release of IM was faster at 50°C than that at 37°C. The drug release amount under NIR light irradiation reached up to 98% over 15 min, which was about 12 times that without NIR light irradiation. The existence of absorbed NIR energy causes shrinkage of thermosensitive polymer chains and successfully caused the drug release. The sorption process was described by the Langmuir model and pseudo‐second‐order kinetic. The drug release kinetics was examined using Zero‐order, First‐order, Korsmeyer–Peppas, and Higuchi mathematical models.

A novel thermosensitive polymer (poly-(NVCL-co-AGE))/MA was synthesized by N-vinylcaprolactam (NVCL), 5-Amino-2-hydroxybenzoic acid (Mesalamine, MA) and allyl glycidyl ether (AGE). The obtained polymeric matrix is functionalized on molybdenum disulfide nanosheets (MNs (which is used as a drug carrier for efficient drug delivery. The ability of MNs -(poly-(NVCL-co-AGE))/MA was estimated as a nanocarrier for the delivery of imatinib mesylate (IM) as an antitumor drug. The resulting polymer was confirmed by FESEM/EDX, TEM, XRD, FTIR, TGA, and UV-Vis spectroscopy. The impacts of various variables such as pH, contact time, and temperature on the adsorption efficiency were also evaluated. Kinetic and isotherm studies of IM adsorption demonstrated that the adsorption of IM on the surface of MNs -(poly-(NVCL-co-AGE))/MA was well fitted to the pseudo-second-order kinetic and Langmuir isotherm mod-els, respectively. On the other hand, we were interested in estimating drug release kinetics and in vitro release behavior of IM loaded on MNs -(poly-(NVCL-co-AGE))/MA. In vitro controlled drug release and phototherapy under near-infrared (NIR) light irradiation are also discussed. The existence of absorbed NIR energy causes shrinkage of thermo-sensitive polymer chains and successfully caused the drug release. In vitro drug release of MNs -(poly-(NVCL-co-AGE))/MA was comparatively carried out at 37 and 50°C. The release rate of MNs -(poly-(NVCL-co-AGE))/MA at 50°C was much higher than those at 37°C. Also, the drug release behavior after the involvement of NIR light irradiation reached up to 98 % over 15 min, which was about 11 times that without NIR light irradiation.