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there are several advantages to the use of transbronchial lung cryobiopsy (TBLC), including less trauma, fewer complications, large and high-quality specimens, and lower cost. This procedure is mainly used for the etiological diagnosis of diffuse parenchymal lung diseases (DPLD) [2] and its most common complications, including bleeding and pneumothorax. Virtual bronchoscopy navigation (VBN) can assist bronchoscopists in pinpointing the target area in the lung and designing an appropriate navigation pathway to accurately reach the target lesion [3]. Thus, VBN improves the rate of diagnosis and reduces the risk of bleeding and pneumothorax. In this report, which we believe to be the first of its kind, we performed TBLC guided by VBN.

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