A highly efficient one‐pot synthesis of the 1,2,4,5‐tetrasubstituted imidazoles and 2,4,5,6‐tetrasubstituted pyrimidines through an arylamidine, malononitrile, and carbonyl compound by using Et3N in CH3CN at reflux conditions was developed. The nature of the carbonyl compounds were different; when the carbonyl compound was arylglyoxal or aryl aldehyde, 1,2,4,5‐tetrasubstituted imidazole and 2,4,5,6‐tetrasubstituted pyrimidine were achieved respectively.
Using the three-component reaction between aryl glyoxals, arylamines, and 2-aminopyridine were synthesized N, 3-diarylimidazo[1,2-a]pyridin-2-amines and 3-aryl-N-(pyridine-2-yl)imidazo[1,2-a]pyridin-2-amines under catalyst-free conditions. Using these starting materials under the same conditions and in the presence of Meldrum's acid as catalyst gave only N, 3-diarylimidazo[1,2-a]pyridin-2-amines. It was observed for the synthesis of these products, Meldrum's acid as catalyst gave 72-89% yields in 1.5-2 hours as against 4-8 hours required to get 53-65 % yields under catalyst-free conditions.
The present work, highlights a highly effective unique procedure for the synthesis of N,3diphenybenzo[d]imidazo[2,1-b]thiazoles and oxybis(1-phenyl-2-(phenylamino)ethanones via the one-pot three-component reaction between aryl glyoxal, aryl amine, and 2-aminobenzothiazole under catalyst-free conditions. The present mild and green method uses EtOH without catalyst at re ux conditions. No catalyst with high yields, availability of the starting materials, operational simplicity, cleaner reaction pro le, no harmful by-products, and the isolated products in pure form are the advantages of this protocol. Structures of all the freshly synthesized products have been deduced by their FT-IR, 1 H-NMR, 13 C-NMR, and elemental analysis.
The present work, highlights a highly effective unique procedure for the synthesis of N,3-diphenybenzo[d]imidazo[2,1-b]thiazoles and oxybis(1-phenyl-2-(phenylamino)ethanones via the one-pot three-component reaction between aryl glyoxal, aryl amine, and 2-aminobenzothiazole under catalyst-free conditions. The present mild and green method uses EtOH without catalyst at reflux conditions. No catalyst with high yields, availability of the starting materials, operational simplicity, cleaner reaction profile, no harmful by-products, and the isolated products in pure form are the advantages of this protocol. Structures of all the freshly synthesized products have been deduced by their FT-IR, 1H-NMR, 13C-NMR, and elemental analysis.
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