Summary - Neuroleptic malignant syndrome is a rare, potentially life-threatening complication which is an unpredictable, idiosyncratic reaction to antipsychotics. In patients receiving traditional antipsychotics, neuroleptic malignant syndrome occurs with an incidence of 0.2-3.3%. However, neuroleptic malignant syndrome also appears in patients treated with atypical antipsychotics, especially Clozapine. A possible cause of neuroleptic malignant syndrome is blockade of dopamine receptors in the nigrostriatal tracts or hypothalamic nuclei. If signs and symptoms of the Neuroleptic malignant syndrome are identified in time, full recovery is possible. This is a report of a female patient with neuroleptic malignant syndrome treated by traditional antipsychotics. As soon as neuroleptic malignant syndrome symptoms were recognized, the antipsychotic drugs were discontinued, symptomatic therapy was initiated and symptoms of neuroleptic malignant syndrome disappeared. However, the patient's psychotic symptoms persisted and an atypical antipsychotic was administered. During the next few days the psychotic symptoms gradually disappeared and the patient accomplished good recovery.
The understanding of psychopathology and treatment practice for patients with GAD in this sample of psychiatrists in Serbia is mostly consistent with the current trends for GAD treatment.
Patients with self-accusing ideas commit suicide most frequently. Delusional depressive patients were at higher suicidal risk; their suicidal thoughts were more intensive than in non-delusional patients; similar results were found in other articles as well.
Sarcoidosis is a multisystem disease of unknown etiology which is characterized by the formation of granulomatous inflammation in various organs and tissues, most commonly in the lungs and lymph nodes. Glucocorticoids are the therapy of choice for the initial treatment of symptomatic disease, but their prolonged use is associated with significant toxicity. Alternative therapies that reduce glucocorticoid use are also available. Fatigue and depression are often present in patients with sarcoidosis. Their occurrence in practice is mostly underestimated, although it is related to a lower quality of life. As fatigue and depression cannot be assessed using objective measures, the use of validated questionnaires is recommended. They enable the detection and monitoring of fatigue and depression related to the underlying disease and may indicate the need for appropriate therapy.
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