No abstract

The Asian summer monsoon is a very important climatic component affecting the land ecosystem on the eastern Asian continent. Here we assess microbe-derived lipid biomarker evidence from a well-dated peat core from Dajiuhu to reconstruct paleotemperature changes in central China through the last 13 ka. The branched fatty alcohol ratio BNA15, which is defined as the relative contribution of branched C15 fatty alcohols over their straight-chain homolog, shows a positive correlation with air temperature ( R= 0.83, n=11, p<0.001) in an altitude transect at Shennongjia Mountain, central China. This correspondence suggests that the microbial activities associated with branched fatty alcohol synthesis are sensitive to differences in temperature. The BNA15 sequence in the Dajiuhu peat deposit shows a trend similar to the paleotemperature record derived from pollen results over the last 13 ka, further supporting that BNA15 is a sensitive proxy of paleotemperature. Absolute temperatures estimated from BNA15 values of modern surface peats are about 3–4°C lower than the modern annual mean air temperature in the peatland, which may result from the influences of factors other than temperature or from the different microbial communities in the mountain soils used to calibrate the BNA15 acidic peats. Fluctuations in the continuous 13 ka BNA15-derived record of relative temperature change from the Dajiuhu peat core imply that solar activity is the dominant cause for most cold events at multicentennial to submillennial timescales.

The current investigations primarily focus on using advanced suspensions to overcome the tradeoff design of ride comfort and handling performance for mining vehicles. It is generally realized by adjusting spring stiffness or damping parameters through active control methods. However, some drawbacks regarding control complexity and uncertain reliability are inevitable for these advanced suspensions. Herein, a novel passive hydraulically interconnected suspension (HIS) system is proposed to achieve an improved ride-handling compromise of mining vehicles. A lumped-mass vehicle model involved with a mechanical-hydraulic coupled system is developed by applying the free-body diagram method. The transfer matrix method is used to derive the impedance of the hydraulic system, and the impedance is integrated to form the equation of motions for a mechanical-hydraulic coupled system. The modal analysis method is employed to obtain the free vibration transmissibilities and force vibration responses under different road excitations. A series of frequency characteristic analyses are presented to evaluate the isolation vibration performance between the mining vehicles with the proposed HIS and the conventional suspension. The analysis results prove that the proposed HIS system can effectively suppress the pitch motion of sprung mass to guarantee the handling performance, and favorably provide soft bounce stiffness to improve the ride comfort. The distribution of dynamic forces between the front and rear wheels is more reasonable, and the vibration decay rate of sprung mass is increased effectively. This research proposes a new suspension design method that can achieve the enhanced cooperative control of bounce and pitch motion modes to improve the ride comfort and handling performance of mining vehicles as an effective passive suspension system. which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Increasing evidence indicates an interaction between dysbiosis of the microbiota and the pathogenesis of schizophrenia. However, limited information is available on the specific microbial communities associated with symptoms of schizophrenia. Therefore, this study aimed to investigate gut microbiota dysbiosis and its relationship with psychopathologies in schizophrenia. We recruited 126 participants and divided them into three groups according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria—acute group (patients with acute schizophrenia), remission group (patients with schizophrenia in remission), and control group (healthy controls). Psychotic symptoms were evaluated using the Positive and Negative Syndrome Scale. Microbiota compositions, diversity and community structure were evaluated using 16S rRNA sequencing. Pearson's correlation analysis was used to evaluate the association between bacterial taxa and psychotic symptoms. The beta-diversity of microbiota composition in the acute group was distinct from that in the remission and control groups (PC1 = 21.11% vs. PC2 = 12.86%, P = 0.021). Furthermore, Pearson's correlation analysis revealed that abundance of Haemophilus was positively correlated with negative psychiatric symptoms (r = 0.303, P = 0.021), while abundance of Coprococcus was negatively correlated with negative psychiatric symptoms (r = −0.285, P = 0.025). Moreover, abundance of Haemophilus was positively correlated with cognition (r = 0.428, P = 0.009), excitement (r = 0.266, P = 0.037), and depression (r = 0.295, P = 0.020). The study findings suggest that alterations in certain gut microbiota may interfere with psychological symptoms in schizophrenia. Our results provide evidence that may help in the development of therapeutic strategies using microbial-based targets. The data that support the findings of this study have been deposited in the NCBI (https://submit.ncbi.nlm.nih.gov/) with accession number SUB9453991.