Objectives: The purpose of this study was to identify the relationship of self-leadership, emotional intelligence, social support, and problem-solving ability of nursing college students, and to understand the factors that affect problem-solving ability.Methods: Participants were in 2nd and 3rd grade of nursing students. The collected data were analyzed by SPSS 22.0 program using descriptive statistics, t-test, ANOVA, correlation, and multiple regression analysis.Results: The significant influencing factors of problem-solving ability were self-leadership. β= 0.36 (<i>p</i>= 0.001), emotional intelligence β= 0.15 (<i>p</i>< 0.04), social support β= 0.29 (<i>p</i>< 0.001) and club activity β= 0.14 (<i>p</i>< 0.02). These factors explained 45.5% of the variance (R<sup>2</sup>= 0.46, <i>p</i>< 0.001).Conclusions: This study showed that problem-solving ability were influencing factors on self-leadership and it is necessary to develop various strategies to improve self leadership in nursing college students.
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