Nontarget high-resolution mass spectrometry (Nt-HRMS) has been proven useful for the identification of unknown poly- and perfluoroalkyl substances (PFASs) in commercial products and water, but applications to biological samples are limited. China is the major PFAS-manufacturing nation; thus, here, we adapted our Nt-HRMS methods to fish collected from the Yangtze River and Tangxun Lake to discover potentially bioaccumulative PFASs in aquatic organisms destined for human consumption. In addition to traditional PFASs, over 330 other fluorinated analytes belonging to 10 classes of PFASs were detected among the pooled fish livers, including 6 sulfonate classes, 2 amine classes, 1 carboxylate class, and 1 N-heterocycle class. One class was detected in samples from both locations, 8 classes were detected exclusively in Tangxun Lake fish, and 1 class was detected exclusively in Yangtze River fish, 10 km downstream of a fluorochemical manufacturing site where we first reported these substances in wastewater 3 years ago. Overall, 4 of the PFAS classes (>165 analytes) are reported for the first time here. Wider monitoring and toxicological testing should be a priority for understanding the health risks posed to people and wildlife exposed to these substances.

Ag NPs and Bphen modified anode and cathode interfaces result in a PCE of 15.75% in perovskite solar cells.

Thus, the formation of more triplet charge-transfer state which possessing microsecond scale lifetime by intersystem crossing from relatively short nanoscale lifetime of 1 CT is benefi cial to increase the current and improve photovoltaic performance. [ 10 ] For example, Holdcroft reported the fi rst photovoltaic study where Ir complexes are coordinated into the conjugated poly(fl uoreneco -phenylpyridine) backbone. [ 11 ] A signifi cant increase of external quantum effi ciency (EQE) from 1.1% of poly(9,9-dihexylfl uoreneco -2-phenylpyridine) to 10.3% of poly(9,9-dioctylfl uoreneco -tris(2-phenylpyridine) iridium (III))) was observed. And 35 times higher of PCE were achieved in polymer/fullerene PV device which could be attributed to the formation of the triplet state in Ir containing polymers. By physically doping Ir(mppy) 3 into P3HT/CdSe hybrid organic solar cells, greatly improved photovoltaic response was observed due to the enhancement of singlet-to-triplet conversion by Ir complex. [ 12 ] Adding a small amount of pqIrpicNa and PEO to P3HT/PC 61 BM solar cell devices, resulted in 20% and 10% increase in the short circuit current ( J SC ) and PCE, respectively, compared to the reference device without additives. [ 13 ] Besides, Cheng and co-workers also reported a series of conjugated polymers bearing indacenodithiophene and cyclometalated platinum complexes, when blended with PC 71 BM, a maximum PCE of 2.9% was obtained. [ 14 ] According to previous results, polymer BHJ solar cells employing heavy metal complexes exhibited PCE no less than 3%. [9][10][11][12][13][14][15][16] It should be noted that BHJ PSCs with PCE over 6% reported so far are all based on singlet CT state dominated pure organic materials. [ 17 ] Therefore, by introducing heavy metal containing triplet component to the previous high effi ciency organic photovoltaic materials is expected to facilitate generation of triplet CT state as well as effectively tailoring of triplet energy levels of 3 CT and 1 T of donor materials through intersystem crossing and thus to improve the device effi ciency.Based on this concept, we introduced various concentrations of triplet iridium complexes (0, 0.5, 1, 1.5, 2.5, and 5 mol%) to the polymer backbone of the famous champion polymer donor material PTB7 which was fi rst reported by Yu and co-workers and exhibited a PCE of 7.4% in simple device structure of Indium tin oxide (ITO)/poly(3,4-ethylenedioxythiophene):poly-

Characteristics of a double-power electrode dielectric barrier discharge of an argon plasma jet generated at the atmospheric pressure are investigated in this paper. Time-averaged optical emission spectroscopy is used to measure the plasma parameters, of which the excitation electron temperature is determined by the Boltzmann's plot method whereas the gas temperature is estimated using a fiber thermometer. Furthermore, the Stark broadening of the hydrogen Balmer Hβ line is applied to measure the electron density, and the simultaneous presence of comparable Doppler, van der Waals, and instrumental broadenings is discussed. Besides, properties of the jet discharge are also studied by electrical diagnosis. It has been found that the electron densities in this argon plasma jet are on the order of 1014 cm−3, and the excitation temperature, gas temperature, and electron density increase with the applied voltage. On the other hand, these parameters are inversely proportional to the argon gas flow rate.

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Retinoblastoma protein (Rb) is an important regulator of vertebrate cell cycle and development. It functions through a direct interaction with protein factors involved in cell cycle progression and differentiation. In the present study we characterized a novel Rb-associated protein, Cream1, which bound to Rb specifically through a C-terminal region. Cream1 contained 959 amino acid residues and migrated as a protein of approx. 120 kDa on SDS/PAGE. It was a widely expressed nuclear protein with a nuclear localization signal resembling that of the large T antigen of simian virus 40. Its primary sequence was characteristic of five direct repeats that were similar to, but distinct from, those of TFII-I, a multifunctional transcription regulator. Three additional regions were also highly conserved in both proteins. Cream1 exhibited an activation activity that was attributed to its N-terminal portion when assayed in yeast. Its relationship with the muscle-enhancer-binding protein MusTRD1 further suggests a role in regulating gene expression. The structural gene, CREAM1, contained 27 exons and spanned more than 150 kb. It was located at human chromosome 7q11.23 in a region deleted for Williams' syndrome, a neurodevelopmental disease with multisystem abnormalities, implying its involvement in certain disorders. Taken together, our results suggest that Cream1 might serve as a positive transcription regulator under the control of Rb.