This work investigated the seasonal variations in biosynthetic path selectivity of nine individual flavonoids, and content and antioxidant activity of three major metabolites in Tetrastigma hemsleyanum. The results revealed that under conditions of precipitation (2.0~6.6 mm), temperature (17.5~24.1°C), humidity (67.3~80.2%) and sunshine duration (3.4~5.8 h) in April and May, the total content of flavonoids reached higher levels between 282 and 394.5 μg/g; in the second half of April with the highest accumulation of flavonoids, the production selectivity (PS) of isoorientin, orientin, rutin, isoquercitin, kaempferol-3-0-rutinoside, astragalin, quercetin, apigenin and kaempferol were 0.30, 0.06, 0.07, 0.07, 0.00, 0.04, 0.38, 0.05 and 0.03, respectively; also according to the reaction network consisting of three main pathways for flavonoids syntheses in T. hemsleyanum, the selectivity of reaction Path II to synthesize quercetin, isoquercitin and rutin in April, May and June fluctuated between 0.52 and 0.66, much higher than that of reaction Path I or Path III.
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