utilization; ii) large variability in prices and availability of data across jurisdictions; iii) rapidly evolving costs in parallel with technological developments; iv) broader impact of medical device beyond clinical effectiveness; v) multiple application across different clinical areas; vi) differences between the published price and actual cost of testing/diagnostics; vii) differences in procurement and reimbursement mechanisms across jurisdictions; viii) reduced confidence in results of the economic evaluation. ConClusions: This case study highlights key challenges in determining and measuring appropriate cost information when conducting economic evaluations of non-drug technologies in Canada, although this may not be unique to Canada. In the absence of good cost information, following appropriate guidance and exploring the parameter values in sensitivity analyses is required.
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