Hydroxyurea and its derivatives exhibit versatile biological activities. Hydroxyurea is currently used in the treatment of various neoplastic and non-neoplastic diseases such as cancer, sickle cell anemia and HIV (1). Derivatives of hydroxyurea were found to inhibit matrix zinc metaloproteinases (MMP), urease, carboanhydrase, carboxypeptidase, cyclooxygenase and 5-lipooxygenase. Early experiments on antibacterial properties and effects on tumor cell lines of hydroxyurea and low molecular mass derivatives were investigated in the 1960s (2-3). Recently, hydroxyurea was recognized as a leading compound in nitric oxide donor synthesis (4).
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