Three new sesquiterpene lactones "acetyltri~oculoside\ 7\04!acetylsalonitenolide and 7!acetylsalonitenolide# and two known ses! quiterpene lactones were isolated from a dichloromethane extract of the Portuguese liverwort Targionia lorbeeriana[ Their structures were established by spectroscopic methods "EI and D:CI mass spectroscopy\ 0 H and 02 C NMR# and that of acetyltri~oculoside was con_rmed by X!ray crystallography[ The three isolated guaianolide sesquiterpene lactones presented antifungal activity against Cladosporium cucumerinum and larvicidal activity against Aedes aegypti[ Only one of the isolated lactones presented activity against Candida albicans[ Þ 0888 Elsevier Science Ltd[ All rights reserved[
This is the first report on the chemical constituents of Asterella blumeana. Three triterpenoids (22-hydroxyhopane, 22,29-dihydroxyhopane, 6a,22-dihydroxyhopane) and one flavonoid (isoscutellarein-7,8,4'-trimethyl ether) were isolated from the CH 2 Cl 2 extract of the liverwort Asterella blumeana grown in vitro. The structures of isolated compounds were established by spectroscopic methods (UV, EI mass spectroscopy, 1 Hand 13 C-NMR). 22,29-dihydroxyhopane is a new natural compound.
The terpenoid constituents of Targionia lorbeeriana grown in vivo and in vitro were com pared. The analysis of the dichloromethane extract was performed by HPLC-UV and by HPLC-M S. The obtained results revealed that the sesquiterpene lactones isolated from the dichloromethane extract of the wild Targionia lorbeeriana were also produced by the liverwort in in vitro cultures, in the same relative amounts.The composition of essential oils was evaluated by GC and GC-MS. Both, the yield and diversity of the essential oil obtained from wild growing T. lorbeeriana gametophytes were higher than those growing in vitro. Although, a significant number of compounds produced in vivo were maintained in vitro, a considerable number of other ones were not detected. Instead, under in vitro conditions, some new compounds were found which do not accumulate under wild conditions.
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