Tricho-dento-osseous syndrome (TDO) is a rare type of dominantly inherited ectodermal dysplasia so far described only in a few families and associated with 3 known mutations in the DLX3 homeobox gene. Here, we describe two families of Finnish origin that segregate features of TDO in several generations. The affected family members have sparse or curly/kinky hair at birth, markedly delayed or advanced dental maturity, defective tooth enamel and dentin, taurodontic molars, multiple dental abscesses and filling of tooth pulps with amorphous denticle-like material as well as an increased density and/or thickness of craniofacial bones. The disease is especially accentuated in one of the families in which the patients develop only lanugo-type hair and the dental abnormalities are severe. After mutational analysis of DLX3, we identified 2 missense mutations affecting the conserved homeodomain. We suggest that TDO is essentially caused by loss of function and haploinsufficiency of DLX3.

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In this paper, we describe our research work to create a Received Signal Strength (RSS) based indoor positioning system to track livestock in a cowshed. We use a vector-based spring network model to localize the nodes. The position information is needed to analyze the behavior of the tracked animals and help the agricultural industry to face the challenges of the technology-driven modernity and care for a large number of animals with a smaller group of people. In our laboratory experiments, we reached a sub-three meter accuracy for a threedimensional positioning environment, which is useful to several use-cases.

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