The relationship between the 15N isotropic chemical shift (δ
iso) or 15N chemical shift tensor
components (δ
11, δ
22, and δ
33) and the main-chain conformationsuch as the right-handed α-helix (αR-helix), left-handed α-helix (αL-helix), left-handed ω-helix (ωL-helix), and antiparallel β-sheet (β-sheet)
forms of 15N-labeled poly(β-benzyl l-aspartate) [Asp*(OBzl)]
n
in the solid statewas studied using solid-state 15N NMR methods. We have found that the δ
iso and δ
22 of Asp*(OBzl) residue were significantly
displaced depending upon conformation: δ
iso (αR-helix, 98.9; αL-helix, 96.8; ωL-helix, 96.3; β-sheet, 100.0
ppm) and δ
22 (αR-helix, 52.8; αL-helix, 48.3; ωL-helix, 47.4; β-sheet, 56.4 ppm). Thus, it became apparent
that the δ
iso and δ
22 are very useful barometers for the conformational analysis, especially for the
determination of the helical sense of [Asp*(OBzl)]
n
in the solid state.
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