Two 2H‐chromenes having a fully substituted benzene ring, 8‐chlorocannabiorcichromene (1) and mycochromenic acid (2), were synthesized by a condensation of salicylaldehydes with isopropylidenemalonate or the thermal cyclization of corresponding propargyl ethers.
Two 2H-chromenes having a fully substituted benzene ring, 8-chlorocannabiorcichromene (1) and mycochromenic acid (2), were synthesized by a condensation of salicylaldehydes with isopropylidenemalonate or the thermal cyclization of corresponding propargyl ethers.
Benzene Ring. -The tetrasubstituted hydroxybenzenes (II) and (VI), prepared by standard procedures, are used as starting materials in the syntheses of 8-chlorocannabiorcichromenic acid (V) and mycochromenic acid (IX). The sequences involve thermal cyclization of the propargyl ethers (III) and (VII), resp., as the key steps. -(YAMAGUCHI*, S.; MAEKAWA, M.; MURAYAMA, Y.; MIYAZAWA, M.; HIRAI, Y.; Tetrahedron Lett. 45 (2004) 37, 6971-6973; Dep. Chem., Fac. Sci., Toyama Univ., Gofuku, Toyama 930, Japan; Eng.) -Roy 52-118
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