The interest to conformational entropy started from developing new drugs. We show the role of conformational component of the entropy in the complex formation between a substance and a specific neuroreceptor, using M-cholinolytics and ligands of µ-opioid receptors as examples. It is shown that conformational entropy may be used for prediction of the drug affinity to a certain receptor. Examples of directed affinity change under their conformational flexibility modification are given. The specific role of the conformational entropy in the receptor's protection from the irreversible inactivation is identified.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.