Recent advances in sensing technology have enabled a new generation of tabletop displays that can sense multiple points of input from several users simultaneously. However, apart from a few demonstration techniques [17], current user interfaces do not take advantage of this increased input bandwidth. We present a variety of multifinger and whole hand gestural interaction techniques for these displays that leverage and extend the types of actions that people perform when interacting on real physical tabletops. Apart from gestural input techniques, we also explore interaction and visualization techniques for supporting shared spaces, awareness, and privacy. These techniques are demonstrated within a prototype room furniture layout application, called RoomPlanner.

We present formulations for compressible and incompressible hyperelastic thin shells which can use general 3D constitutive models. The necessary plane stress condition is enforced analytically for incompressible materials and iteratively for compressible materials. The thickness stretch is statically condensed and the shell kinematics are completely described by the first and second fundamental forms of the midsurface. We use C 1 -continuous isogeometric discretizations to build the numerical models. Numerical tests, including structural dynamics simulations of a bioprosthetic heart valve, show the good performance and applicability of the presented methods.

This paper builds on a recently developed immersogeometric fluid–structure interaction (FSI) methodology for bioprosthetic heart valve (BHV) modeling and simulation. It enhances the proposed framework in the areas of geometry design and constitutive modeling. With these enhancements, BHV FSI simulations may be performed with greater levels of automation, robustness and physical realism. In addition, the paper presents a comparison between FSI analysis and standalone structural dynamics simulation driven by prescribed transvalvular pressure, the latter being a more common modeling choice for this class of problems. The FSI computation achieved better physiological realism in predicting the valve leaflet deformation than its standalone structural dynamics counterpart.

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Isogeometric analysis (IGA) has been a particularly impactful development in the realm of Kirchhoff-Love thin-shell analysis because the high-order basis functions employed naturally satisfy the requirement of C 1 continuity. Still, engineering models of appreciable complexity, such as wind turbine blades, are typically modeled using multiple surface patches and, often, neither rotational continuity nor conforming discretization can be practically obtained at patch interfaces. A penalty approach for coupling adjacent patches is therefore presented. The proposed method imposes both displacement and rotational continuity and is applicable to either smooth or nonsmooth interfaces and either matching or non-matching discretization. The penalty formulations require only a single, dimensionless penalty coefficient for both displacement and rotation coupling terms, alleviating the problem-dependent nature of the penalty parameters. Using this coupling methodology, numerous benchmark problems encapsulating a variety of analysis types, geometrical and material properties, and matching and non-matching interfaces are addressed. The coupling methodology produces consistently accurate results throughout all tests. Furthermore, the suggested penalty coefficient of α = 10 3 is shown to be effective for the wide range of problem configurations addressed. Finally, a realistic wind turbine blade model, consisting of 27 patches and 51 coupling interfaces and having a chordwise-and spanwise-variant composite material definition, is subjected to buckling, vibration, and nonlinear deformation analysis using the proposed approach.

A number of isomer structures can be formed in hydrogen-bonded clusters, reflecting the essential variety of structural motifs of hydrogen bond networks. Control of isomer distribution of a cluster is important not only in practical use for isomer-specific spectroscopy but also in understanding of isomerization processes of hydrogen bond networks. Protonated methanol clusters have relatively simple networks and they are model systems suitable to investigate isomer distribution changes. In this paper, isomer distribution of H(+)(CH(3)OH)(7) is studied by size-selective infrared spectroscopy in the OH and CH stretching vibrational region and density functional theory calculations. While the clusters produced by a supersonic jet expansion combined with electron ionization were predominantly isomers having open hydrogen bond networks such as a linear chain, the Ar or Ne attachment (so-called rare gas tagging) entirely switches the isomer structures to compactly folded ones, which are composed only of closed multiple rings. The origin of the isomer switching is discussed in terms of thermal effects and specific isomer preference.

We previously demonstrated that blockade of immune suppressive CTLA-4 resulted in tumor growth delay when combined with chemotherapy in murine mesothelioma. Tumor-infiltrating T cells (TIT) after local radiotherapy (LRT) play critical roles in abscopal effect against cancer. We attempt to improve the local and abscopal effect by modulating T cell immunity with systemic blockade of CTLA-4 signal. The growth of primary tumors was significantly inhibited by LRT while CTLA-4 antibody enhanced the antitumor effect. Growth delay of the second tumors was achieved when the primary tumor was radiated. LRT resulted in more T cell infiltration into both tumors, including Treg and cytotoxic T cells. Interestingly, the proportion of Treg over effector T cells in both tumors was reversed after CTLA-4 blockade, while CD8 T cells were further activated. The expression of the immune-related genes was upregulated and cytokine production was significantly increased. LRT resulted in an increase of TIT, while CTLA-4 blockade led to significant reduction of Tregs and increase of cytotoxic T cells in both tumors. The abscopal effect is enhanced by targeting the immune checkpoints through modulation of T cell immune response in murine mesothelioma.

Mobile phones can provide a number of benefits to older people. However, most mobile phone designs and form factors are targeted at younger people and middle-aged adults. To inform the design of mobile phones for seniors, we ran several participatory activities where seniors critiqued current mobile phones, chose important applications, and built their own imagined mobile phone system. We prototyped this system on a real mobile phone and evaluated the seniors' performance through user tests and a real-world deployment. We found that our participants wanted more than simple phone functions, and instead wanted a variety of application areas. While they were able to learn to use the software with little difficulty, hardware design made completing some tasks frustrating or difficult. Based on our experience with our participants, we offer considerations for the community about how to design mobile devices for seniors and how to engage them in participatory activities.