Synthetase Inhibitors. -Starting with a micromolar lead identified from high-throughput screening, a series of pyrazoles [cf. (VIII), (IX)] are discovered with significantly improved potency on bacterial methionyl-tRNA synthetase and selectivity over human methionyl-tRNA synthetase. -(FINN*, J.; MATTIA, K.; MORYTKO, M.; RAM, S.; YANG, Y.; WU, X.; MAK, E.; GALLANT, P.; KEITH, D.; Bioorg.
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