Exposure to estrogenic compounds may pose a developmental hazard to infants. Soy products, which contain the phytoestrogens, genistein and daidzein, are becoming increasingly popular as infant foods. To begin to evaluate the potential of the phytoestrogens in these products to affect infants, we measured total genistein and daidzein contents of commercially available soy-based infant formulas, infant cereals, dinners, and rusks. We also assayed phytoestrogens in dairy-based formulas and in breast milk from omnivorous or vegetarian mothers. In most cases, the glucoside forms of the phytoestrogens were hydrolyzed before separation by HPLC. Mean (+/-SEM) total genistein and daidzein contents in four soy infant formulas were 87+/-3 and 49+/-2 microg/g, respectively. The phytoestrogen content of cereals varied with brand, with genistein ranging from 3-287 microg/g and daidzein from 2-276 microg/g. By contrast, no phytoestrogens were detected in dairy-based infant formulas or in human breast milk, irrespective of the mother's diet (detection limit = 0.05 microg/ml). When fed according to the manufacturer's instruction, soy formulas provide the infant with a daily dose rate of total isoflavones (i.e., genistein + daidzein) of approximately 3 mg/kg body weight, which is maintained at a fairly constant level between 0-4 months of age. Supplementing the diet of 4-month-old infants with a single daily serving of cereal can increase their isoflavone intake by over 25%, depending on the brand chosen. This rate of isoflavone intake is much greater than that shown in adult humans to alter reproductive hormones. Since the available evidence suggests that infants can digest and absorb dietary phytoestrogens in active forms and since neonates are generally more susceptible than adults to perturbations of the sex steroid milieu, we suggest that it would be highly desirable to study the effects of soy isoflavones on steroid-dependent developmental processes in human babies.
Our aims were to measure isoflavone intake from soy- and dairy-based infant formulas and breast milk and to assess the ability of infants to digest and absorb soy isoflavones by measuring daily urinary excretion rates. We recruited 29 infants: 4 received soy-based formula and 25 received dairy-based formula. We collected pooled urine samples from 3-5 disposable diapers worn during a 24-h period and developed and validated methods for extracting isoflavones from the diapers. Infants were studied every 1 or 2 wk, starting at 2-6 wk of age and continuing until 16 wk. Only soy-based formulas contained isoflavones in concentrations detectable by HPLC (limits: 0.05 mg/L for liquids and 0.1 mg/kg for solids). Soy-based formulas provided a mean (+/-SEM) daily dose of isoflavones (genistein plus daidzein) of 3.2 +/- 0.2 mg/kg body wt, which remained fairly constant (CV: 12%) regardless of age < or = 16 wk. Isoflavones were measurable in all samples from soy-fed infants, but not in urine from dairy-fed infants. Daily isoflavone excretion rates varied little among infants [range of mean individual values (mg x kg(-1) d(-1)): daidzein, 0.37 +/- 0.03 to 0.58 +/- 0.06; genistein, 0.15 +/- 0.03 to 0.32 +/- 0.04] and did not change with age < or = 16 wk. The mean percentage of the daily intake recovered in the urine of soy-fed infants was 38 +/- 4% for daidzein and 13 +/- 3% for genistein, and remained constant with age. These values are similar to those for adults and indicate that young infants are able to digest, absorb, and excrete genistein and daidzein from soy-based formulas as efficiently as do adults consuming soy products.
The first part of this review of Mac Giolla Phádraig Osraí history (1384-1534) covers the period 1384, from the conquest of Richard II, to 1454, by which time the clan had entered into an alliance with their mortal enemies, the Butlers of Ormond. Twelve years after the commencement of this era the Lordship of Ossory had fallen to Finghin Óg; these were days of increasing formation of alliances between Gaelic chieftains. That changed around the time of Finghin Óg’s death in ca. 1417; the power struggle between Sir John Talbot and Sir James Butler, 4th Earl of Ormond, altered the face of Irish politics for the next 30 or so years, and Mac Giolla Phádraig Osraí had to choose one side or the other. It was a time when Donnchadh Mór, a previously unrecognised Lord of Ossory, was chieftain. His life and times are recounted from entries in the Annals of the Four Masters and other familiar texts, but three largely overlooked sources of Mac Giolla Phádraig Osraí history – Liber Ruber, the Ormond Deeds and the Kildare Rental – significantly add to our understand of both he and Mac Giolla Phádraig Osraí lineages, which to date have been muddled. New characters are uncovered, such as Morena ny Giolla Phádraig and her husband, John the Blind Butler, and the previously ignored branch, Clann Maeleachlainn Ruadh. An account of the early stages of the Ormond-Mac Giolla Phádraig Osraí alliance, which would ultimately fragment the clan, is provided.
Mac Giolla Phádraig Clerics 1394-1534 AD is a three-part series, which provides an account of all known individual Mac Giolla Phádraig clerics in the late medieval era and details their temporalities, occupations, familial associations, and broader networks. The ultimate goal of the series is the full contextualisation of all available historical records relating to Mac Giolla Phádraig clerics alongside the genealogical record that can be extracted by twenty-first century science – that being the science of Y-DNA. The Papal Registers, in particular, record numerous occurrences of Mac Giolla Phádraig clerics, predominantly in the dioceses of Cill Dalua (Killaloe) and Osraí (Ossory), from the late fourteenth to the early sixteenth century. Yet, no small intrigue surrounds their emergence. Part I of Mac Giolla Phádraig Clerics 1394-1534 AD examines the context surrounding the earliest appointments of Mac Giolla Phádraig clerics, which is in neither Cill Dalua nor Osraí but the diocese of Luimneach (Limerick). Once that context is understood, a pattern of associations emerges. A ‘coincidental’ twenty-first century surname match from the Fitzpatrick Y-DNA project leads to a review of the relationship between the FitzMaurice of Ciarraí (Kerry) clerics and Jordan Purcell, Bishop of Cork and Cloyne (1429-1472). The ‘coincidence’ then leads to an examination of a close Y-DNA match between men of the surnames Purcell and Hennessey. That match, coupled with the understanding that Nicholas Ó hAonghusa (O’Hennessey), elected Bishop of Lismore and Waterford (1480-1483) but with opposition, is considered a member of Purcell’s household, transforms the ‘coincidence’ into a curiosity. Part I morphs into a conversation, likely uncomfortable for some, relating to clerical concubinage, illegitimacy, and the ‘lubricity’ of the prioress and her nuns at the Augustinian nunnery of St Catherine's O’Conyll. The nunnery was located at Mainistir na gCailleach Dubh (Monasternagalliaghduff), which lay just a stone’s throw from where Bishop Jordan Purcell and Matthew Mac Giolla Phádraig, the first Mac Giolla Phádraig cleric recorded in the Papal Registers, emerged. Part I makes no judgments and draws no firm conclusions but prepares the reader for Part II by ending with some questions. Do the Mac Giolla Phádraig clerics of Osraí, who rose to prominence in the late-fifteenth century, have their origins in Deasmhumhain (Desmond)? Could the paternal lineages of Mac Giolla Phádraig clerics be, at least from the mid-fourteenth century, with the house of the Geraldine FitzMaurice clerics of Ciarraí? And, could some of the modern-day descendants of the Mac Giolla Phádraig clerics be those Costigans, FitzGeralds, and Fitzpatricks who are found under haplotype R-A1488?
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