Von Willebrand disease (VWD) is a common hereditary or acquired bleeding disorder in dogs, and is characterized by an abnormality in Von Willebrand factor (VWF), which is a glycoprotein that plays an essential role in platelet adhesion and aggregation during primary hemostasis. Most dog breeds, including the Dobermann, have DvW type I, with autosomal dominant inheritance with incomplete penetrance in some breeds and autosomal recessive in others, caused by a decrease in the total concentration of vWf, with all multimers present, but in reduced amounts. Given the importance of this disease, taking into account the clinical signs, such as prolonged bleeding, the objective literature review, through a survey of the literature, develop and detail scientific, genetic and clinical knowledge in relation to Von Willebrand disease in dogs, in addition to understanding the genetic influence on the severity and transmission of the disease.
RESUMO:O Brasil é destaque na exportação de carne bovina. A mercadoria fica entre os 10 produtos mais vendidos internacionalmente pelo país, contribuindo significativamente com o Produto Interno Bruto (PIB). O destaque é resultado, principalmente, da aplicação de biotécnicas modernas de reprodução que atuam melhorando o material genético de um rebanho. Essas biotécnicas podem contribuir com os resultados satisfatórios de diversas formas: melhora a genética sem comprometer a variabilidade; reduz o intervalo entre as gerações; permite um melhor aproveitamento do potencial genético dos machos e aumenta substancialmente a eficiência do rebanho. Portanto, devido ao impacto das biotécnicas no cenário econômico mundial e a escassez de materiais que abordam o tema na literatura, a presente revisão literária objetivou descrever as principais biotécnicas reprodutivas que contribuem com a aceleração do melhoramento genético em bovinos.
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