This paper presents a comparison study between 10 automatic and six interactive methods for liver segmentation from contrast-enhanced CT images. It is based on results from the "MICCAI 2007 Grand Challenge" workshop, where 16 teams evaluated their algorithms on a common database. A collection of 20 clinical images with reference segmentations was provided to train and tune algorithms in advance. Participants were also allowed to use additional proprietary training data for that purpose. All teams then had to apply their methods to 10 test datasets and submit the obtained results. Employed algorithms include statistical shape models, atlas registration, level-sets, graph-cuts and rule-based systems. All results were compared to reference segmentations five error measures that highlight different aspects of segmentation accuracy. All measures were combined according to a specific scoring system relating the obtained values to human expert variability. In general, interactive methods reached higher average scores than automatic approaches and featured a better consistency of segmentation quality. However, the best automatic methods (mainly based on statistical shape models with some additional free deformation) could compete well on the majority of test images. The study provides an insight in performance of different segmentation approaches under real-world conditions and highlights achievements and limitations of current image analysis techniques.

Abstract. Since their introduction as a means of front propagation and their first application to edge-based segmentation in the early 90's, level set methods have become increasingly popular as a general framework for image segmentation. In this paper, we present a survey of a specific class of region-based level set segmentation methods and clarify how they can all be derived from a common statistical framework.Region-based segmentation schemes aim at partitioning the image domain by progressively fitting statistical models to the intensity, color, texture or motion in each of a set of regions. In contrast to edge-based schemes such as the classical Snakes, region-based methods tend to be less sensitive to noise. For typical images, the respective cost functionals tend to have less local minima which makes them particularly well-suited for local optimization methods such as the level set method.We detail a general statistical formulation for level set segmentation. Subsequently, we clarify how the integration of various low level criteria leads to a set of cost functionals and point out relations between the different segmentation schemes. In experimental results, we demonstrate how the level set function is driven to partition the image plane into domains of coherent color, texture, dynamic texture or motion. Moreover, the Bayesian formulation allows to introduce prior shape knowledge into the level set method. We briefly review a number of advances in this domain.

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