The prevalence of sexual dysfunction in schizophrenia patients was investigated as part of this large (n = 7655), prospective, international (27 countries) study. Based on patient reports, sexual dysfunction affected approx. 50% of patients and the prevalence of complaints varied significantly between regions (p < 0.0001). The prevalence of sexual dysfunction, as perceived by psychiatrists, also varied significantly across regions (p < 0.0001). Psychiatrists significantly underestimated the presence of impotence/sexual dysfunction (p < 0.0001) and loss of libido (p < 0.0001), compared to reports from patients. The frequency of sexual dysfunction was significantly higher in patients who had been using prolactin-elevating antipsychotics prior to study entry, compared to those who had been treated with prolactin-sparing antipsychotics (patient reports, p = 0.002; psychiatrist perception, p = 0.0004). This study has shown that the prevalence of sexual dysfunction is high in both male and female patients with schizophrenia and frequently underestimated by psychiatrists. Regional variation is evident in both psychiatrist perceptions and patient reports of sexual dysfunction. Given the importance of sexual function to quality of life and treatment compliance, proactive assessment of sexual function is required to optimize schizophrenia management.

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Two distinct Permian volcanic epochs were revealed in the Pannonian Basin (eastern Central Europe) by U-Pb zircon geochronology: an older one (~ 281 Ma, Cisuralian) in the ALCAPA Mega-unit (Central Transdanubia, Hungary) and a younger volcanic episode (~ 267-260 Ma, Guadalupian) in the Tisza Mega-unit (Southern Transdanubia and the eastern Pannonian Basin, Hungary). The former is represented by dacitic subvolcanic rocks (dykes) and lavas, while the latter is dominantly by crystal-rich rhyolitic-rhyodacitic/dacitic ignimbrites and subordinate rhyodacitic/dacitic lavas. Whole-rock (major and trace element) geochemical data and zircon U-Pb ages suggest close relationship between the samples of Central Transdanubia and volcanic rocks of the Northern Veporic Unit (Western Carpathians, Slovakia), both being part of the ALCAPA Mega-unit. Such correlation was also revealed between the Permian felsic volcanic rocks of the Apuseni Mts (Romania) and the observed samples of Southern Transdanubia and the eastern Pannonian Basin that are parts of the Tisza Mega-unit. The older volcanic rocks (~ 281-265 Ma) could be linked to post-orogenic tectonic movements, however, the youngest samples (~ 260 Ma, eastern Pannonian Basin, Tisza Mega-unit) could be formed in the extensional setting succeeding the post-collisional environment. On the whole, the observed Permian magmatic rocks show significant similarity with those of the Western Carpathians.