BACKGROUND Pemphigusis a bullous, rare and chronic autoimmune disease. There are two
major forms of pemphigus: vulgaris and foliaceus. Epidemiological data and
clinical outcome in patients diagnosed in the Brazilian Amazon states are
still rare. OBJECTIVES To study the occurrence of the disease during the study period and analyze
the epidemiological profile of patients, the most common subtype of
pemphigus, and the clinical evolution of patients. METHODS Retrospective analysis of medical records of hospitalized patients with
pemphigus foliaceus and pemphigus vulgaris in the period from 2003 to 2010
in Dermatology Service of Hospital Fundação Santa Casa de Misericórdia do
Pará, Belém, Northern Brazil. RESULTS We found a total of 20 cases of pemphigus during the study period, 8 of
which were of foliaceus pemphigus and 12 of vulgaris pemphigus. Pemphigus
foliaceus had the predominance of male patients (75%), showed satisfactory
clinical evolution, and was characterized by absence of pediatric cases.
Pemphigus vulgaris affected more women (66.7%), showed mean hospital stay of
1 to 3 months (50%), and there were three cases of death (25%). The
prescribed immunosuppressive drugs included prednisone with or without
combination of azathioprine and/or dapsone. Sepsis was associated with 100%
of the deaths. CONCLUSIONS The occurrence of the disease is rare, there are no familiar/endemic
outbreaks in the sample. Evolution is usually favorable, but secondary
infection is associated with worse prognosis. The choice of best drugs to
treat pemphigus remains controversial.
Introduction: Moderate and severe forms of psoriasis require phototherapy and/or systemic medications. The UVB band, with wavelength between 311 and 312nm, is called narrowband UVB (NB-UVB) and it has proven to be more beneficial for the psoriasis treatment.
Goals: to characterize the group of patients with psoriasis treated with NB-UVB phototherapy, according to the clinical form, sex, phototype, and clinical evolution.
Methods: All patients with psoriasis who underwent NB-UVB phototherapy between August 2016 and April 2017 were included in this study. Data on the patients were collected retrospectively.
Results: During the study, 19 patients were treated with NB-UVB phototherapy, being 09 women (47%) and 10 men (53%), ages ranging from 22 to 81years. The most prevalent phototypes were III (42%) and IV (37%). Only 04 patients (21%) had guttate psoriasis and 15 (79%) had psoriasis vulgaris with variable severity. The total number of phototherapy sections, during the period evaluated, varied from 7 to 51, with an average of 25 sessions. It was observed that, 09 patients (47%) had a response beginning with up to two months of treatment. The minimum number of sections to start improvement varied from 8 to 28, with an average of 16 sessions.
Conclusions: The use of NB-UVB phototherapy proved to be a safe and effective treatment, and should be considered a good therapeutic option for psoriasis.
An atopic breast eczema is usually bilateral, with intense pruritus and good response to corticosteroids. The differential diagnosis with mammary Paget's disease is fundamental, mainly in unilateral clinical manifestations, since it is frequently associated to adjacent breast tumors. The aim of the present report was to present a clinical condition of an atopic breast eczema through an exuberant and unilateral clinical presentation, emphasizing the need of the differential diagnosis for malignant diseases at this location.
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