In order to describe the prevalence of hypercholesterolemia and hypertriglyceridemia in a cohort of HIV-infected children and adolescents in Latin America and to determine associations with highly active antiretroviral therapy (HAART), we performed this cross-sectional analysis within the NICHD International Site Development Initiative pediatric cohort study. Eligible children had to be at least 2 years of age and be on HAART. Among the 477 eligible HIV-infected youth, 98 (20.5%) had hypercholesterolemia and 140 (29.4%) had hypertriglyceridemia. In multivariable analyses, children receiving protease inhibitor (PI)-containing HAART were at increased risk for hypercholesterolemia [adjusted odds ratio (AOR) = 2.7, 95% confidence interval (CI) 1.3-5.6] and hypertriglyceridemia (AOR = 3.5, 95% CI 1.9-6.4) compared with children receiving non-nucleoside reverse transcriptase inhibitor (NNRTI)-containing HAART. In conclusion, HIV-infected youth receiving PI-containing HAART in this Latin American cohort were at increased risk for hypercholesterolemia and hypertriglyceridemia compared with those receiving NNRTI-containing HAART.
El objetivo del estudio fue determinar las necesidades de atención dental de pacientes pediátricos con VIH/SIDA mediante el índice CPO-D, índice de higiene oral simplificado y la prevalencia de maloclusiones, así como evaluar la concordancia entre los índices. Métodos: Se incluyeron 47 pacientes con VIH/SIDA atendidos en la Clínica de Inmunodeficiencias (CLINDI) del Hospital Infantil de México “Federico Gómez”. La evaluación de la concordancia entre los índices IHOS y CPO-D se realizó con los datos en escala continua y agrupados en categorías; para ello se utilizó el coeficiente de correlación intraclase con un nivel de significancia de 0.05. Resultados: El 93% de pacientes tuvieron higiene oral regular y el 62% de los pacientes con dentición permanente presentó maloclusión. Asimismo, se observó una aparente discordancia entre los índices CPO-D e IHOS. Conclusión: Los resultados no son los esperados para niños que están siendo tratados en un hospital de tercer nivel.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.