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BackgroundPreventive measures are essential to limit the spread of new viruses; their uptake is key to their success. However, the vaccination uptake in pandemic outbreaks is often low. We aim to elicit how disease and vaccination characteristics determine preferences of the general public for new pandemic vaccinations.MethodsIn an internet-based discrete choice experiment (DCE) a representative sample of 536 participants (49% participation rate) from the Dutch population was asked for their preference for vaccination programs in hypothetical communicable disease outbreaks. We used scenarios based on two disease characteristics (susceptibility to and severity of the disease) and five vaccination program characteristics (effectiveness, safety, advice regarding vaccination, media attention, and out-of-pocket costs). The DCE design was based on a literature review, expert interviews and focus group discussions. A panel latent class logit model was used to estimate which trade-offs individuals were willing to make.ResultsAll above mentioned characteristics proved to influence respondents’ preferences for vaccination. Preference heterogeneity was substantial. Females who stated that they were never in favor of vaccination made different trade-offs than males who stated that they were (possibly) willing to get vaccinated. As expected, respondents preferred and were willing to pay more for more effective vaccines, especially if the outbreak was more serious (€6–€39 for a 10% more effective vaccine). Changes in effectiveness, out-of-pocket costs and in the body that advises the vaccine all substantially influenced the predicted uptake.ConclusionsWe conclude that various disease and vaccination program characteristics influence respondents’ preferences for pandemic vaccination programs. Agencies responsible for preventive measures during pandemics can use the knowledge that out-of-pocket costs and the way advice is given affect vaccination uptake to improve their plans for future pandemic outbreaks. The preference heterogeneity shows that information regarding vaccination needs to be targeted differently depending on gender and willingness to get vaccinated.

Dynamic traffic simulation models are frequently used to support decisions when planning an evacuation. This contribution reviews the different (mathematical) model formulations underlying these traffic simulation models used in evacuation studies and the behavioural assumptions that are made. The appropriateness of these behavioural assumptions is elaborated on in light of the current consensus on evacuation travel behaviour, based on the view from the social sciences as well as empirical studies on evacuation behaviour. The focus lies on how travellers' decisions are predicted through simulation regarding the choice to evacuate, departure time choice, destination choice, and route choice. For the evacuation participation and departure time choice we argue in favour of the simultaneous approach to dynamic evacuation demand prediction using the repeated binary logit model. For the destination choice we show how further research is needed to generalize the current preliminary findings on the location-type specific destination choice models. For the evacuation route choice we argue in favour of hybrid route choice models that enable both following instructed routes and en-route switches. Within each of these discussions, we point at current limitations and make corresponding suggestions on promising future research directions.

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This paper compares different types of simulated draws over a range of number of draws in generating Bayesian efficient designs for stated choice (SC) studies. The paper examines how closely pseudo Monte Carlo, quasi Monte Carlo and Gaussian quadrature methods are able to replicate the true levels of Bayesian efficiency for SC designs of various dimensions. The authors conclude that the predominantly employed method of using pseudo Monte Carlo draws is unlikely to result in leading to truly Bayesian efficient SC designs. The quasi Monte Carlo methods analyzed here (Halton, Sobol, and Modified Latin Hypercube Sampling) all clearly outperform the pseudo Monte Carlo draws. However, the Gaussian quadrature method examined in this paper, incremental Gaussian quadrature, outperforms all, and is therefore the recommended approximation method for the calculation of Bayesian efficiency of stated choice designs.