The Gemini Multi-conjugate Adaptive Optics System -GeMS, a facility instrument mounted on the Gemini South telescope, delivers a uniform, near diffraction limited images at near infrared wavelengths (0.95 µm -2.5 µm) over a field of view of 120 . GeMS is the first sodium layer based multi laser guide star adaptive optics system used in astronomy. It uses five laser guide stars distributed on a 60 square constellation to measure for atmospheric distortions and two deformable mirrors to compensate for it. In this paper, the second devoted to describe the GeMS project, we present the commissioning, overall performance and operational scheme of GeMS. Performance of each sub-system is derived from the commissioning results. The typical image quality, expressed in full with half maximum, Strehl ratios and variations over the field delivered by the system are then described. A discussion of the main contributor to performance limitation is carried-out. Finally, overheads and future system upgrades are described.
PURPOSE Combination treatment with BRAF and MEK inhibitors has demonstrated benefits on progression-free survival (PFS) and overall survival (OS) and is a standard of care for the treatment of advanced BRAF V600–mutant melanoma. Here, we report the 5-year update from the COLUMBUS trial (ClinicalTrials.gov identifier: NCT01909453 ). METHODS Patients with locally advanced unresectable or metastatic BRAF V600–mutant melanoma, untreated or progressed after first-line immunotherapy, were randomly assigned 1:1:1 to encorafenib 450 mg once daily plus binimetinib 45 mg twice daily, vemurafenib 960 mg twice daily, or encorafenib 300 mg once daily. An updated analysis was conducted 65 months after the last patient was randomly assigned. RESULTS Five hundred seventy-seven patients were randomly assigned: 192 to encorafenib plus binimetinib, 191 to vemurafenib, and 194 to encorafenib. The 5-year PFS and OS rates with encorafenib plus binimetinib were 23% and 35% overall and 31% and 45% in those with normal lactate dehydrogenase levels, respectively. In comparison, the 5-year PFS and OS rates with vemurafenib were 10% and 21% overall and 12% and 28% in those with normal lactate dehydrogenase levels, respectively. The median duration of response with encorafenib plus binimetinib was 18.6 months, with disease control achieved in 92.2% of patients. In comparison, the median duration of response with vemurafenib was 12.3 months, with disease control achieved in 81.2% of patients. Long-term follow-up showed no new safety concerns, and results were consistent with the known tolerability profile of encorafenib plus binimetinib. Interactive visualization of the data presented in this article is available at COLUMBUS dashboard. CONCLUSION In this 5-year update of part 1 of the COLUMBUS trial, encorafenib plus binimetinib treatment demonstrated continued long-term benefits and a consistent safety profile in patients with BRAF V600–mutant melanoma.
Cosmic collisions on planets cause detectable optical flashes that range from terrestrial shooting stars to bright fireballs. On June 3, 2010 a bolide in Jupiter's atmosphere was simultaneously observed from the Earth by two amateur astronomers observing Jupiter in red and blue wavelengths. The bolide appeared as a flash of 2 s duration in video recording data of the planet. The analysis of the light curve of the observations results in an estimated energy of the impact of 0.9-4.0x10 15 J which corresponds to a colliding body of 8-13 m diameter assuming a mean density of 2 g cm -3 . Images acquired a few days later by the Hubble Space Telescope and other large ground-based facilities did not show any signature of aerosol debris, temperature or chemical composition anomaly, confirming that the body was small and destroyed in Jupiter's upper atmosphere. Several collisions of this size may happen on Jupiter on a yearly basis. A systematic study of the impact rate and size of these bolides can enable an empirical determination of the flux of meteoroids in Jupiter with implications for the populations of small bodies in the outer Solar System and may allow a better quantification of the threat of impacting bodies to Earth. The serendipitous recording of this optical flash opens a new window in the observation of Jupiter with small telescopes.
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