Background The COVID-19 pandemic has been an unprecedented and potentially stressful event that inserted itself into the 2019–2020 Canadian medical curriculum. However, its impact on stress and subsequent professional pathways is not well understood. This study aims to assess the impact of the COVID-19 pandemic on the mental well-being, training, and career choices of Canadian medical clerks within the first three months of the pandemic. It also aims to assess their use of university support systems and their appreciation of potential solutions to common academic stressors. Methods An electronic survey composed of four sections: demographics, stressors experienced during the pandemic, World Health Organization (WHO) well-being index, and stress management and resources was distributed to Canadian clerks. Results Clerks from 10 of the 17 Canadian medical faculties participated in this study (n = 627). Forty-five percent of clerks reported higher levels of stress than usual; 22% reconsidered their residency choice; and 19% reconsidered medicine as a career. The factors that were most stressful among clerks were: the means of return to rotations; decreased opportunities to be productive in view of residency match; and taking the national licensing exam after the beginning of residency. The mean WHO well-being index was 14.8/25 ± 4.5, indicating a poor level of well-being among a considerable proportion of students. Clerks who reconsidered their residency choice or medicine as a career had lower mean WHO well-being indices. Most clerks agreed with the following suggested solutions: training sessions on the clinical management of COVID-19 cases; being allowed to submit fewer reference letters when applying to residency; and having protected time to study for their licensing exam during residency. Overall, clerks were less concerned with being infected during their rotations than with the impact of the pandemic on their future career and residency match. Conclusion The COVID-19 pandemic had a considerable impact on the medical curriculum and well-being of clerks. A number of student-identified solutions were proposed to reduce stress. The implementation of these solutions throughout the Canadian medical training system should be considered.
Breast cancer is the leading cause of cancer deaths amongst American women aged 20 to 59. While the incidence of breast cancer has been increasing, its mortality rates have significantly declined from 1989 to 2016. As a result, the number of survivors considerably increased. This impacts the detection and management of recurrences. Peritoneal metastases from breast cancer is a rare and challenging clinical presentation. There is a lack of knowledge syntheses and specific recommendations for the management of breast cancer peritoneal metastases. This review aims to determine the pattern of spread, prognosis, diagnosis, and role of surgery in this subset of patients.Relevant studies were searched in PubMed and Web of Science between April and June 2019. Included studies were written in English and reported data on breast cancer peritoneal or gastrointestinal metastases. Articles published before 1990, case reports, editorials, and articles with no full text available were excluded. Data abstraction was performed for citation information, population, sample, methods, relevant results, mentioned limitations, and study design.The search identified 505 unique reports. A total of 21 articles were included in the synthesis. Sixteen articles were observational studies, four were experimental, and one article was a proof-of-concept study. Amongst all observational studies, the diagnostic methods and criteria for breast cancer carcinomatosis were particularly heterogeneous, including ascites cytology, biopsy, surgical exploration, and various computed tomography (CT) findings. The majority of pathology and imaging reports demonstrated that breast cancer peritoneal metastases are mainly associated with invasive lobular carcinoma (ILC) and the following intrinsic subtypes: HER2-enriched, luminal B and basal-like. Experimental studies demonstrated that peritoneal metastases can be studied using breast cancer xenograft models. Somatic loss of both p53 and E-cadherin was associated with ILC peritoneal spread. Studies on prognosis and treatment highlighted that peritoneal metastases were associated with a poorer prognosis than other metastatic sites. In terms of surgical management, there is a paucity of data on the outcomes of hyperthermic intraperitoneal chemotherapy (HIPEC) in these patients. However, included studies suggested a role for cytoreductive surgery in selected patients when there is no residual disease after the procedure.This review summarizes data on the development, diagnosis, prognosis, and treatment of breast cancer peritoneal and gastrointestinal metastases. Patients’ survival is significantly reduced in comparison with other distant metastatic sites. A deeper understanding of the invasion mechanisms and the role of surgery will be important.
IntroductionTargeted axillary dissection (TAD) is a novel technique in the field of surgical oncology. During TAD, patients with node-positive breast cancer who clinically responded to neoadjuvant chemotherapy undergo resection of a previously proven metastatic node together with sentinel lymph node dissection (SLND). We aimed to assess the success rates of seed insertion and seed retrieval in the Canadian setting, as well as hospital costs of the procedure. MethodsPatients converted to clinically node-negative status post-neoadjuvant chemotherapy underwent TAD. Before surgery, an iodine-125 radioactive seed was inserted in the previously proven metastatic node. The seed node was resected together with an SLND. Axillary lymph node dissection (ALND) was performed in all patients with residual metastases. ResultsRadioactive seeds were successfully inserted in 34/35 patients. In 34 patients, the targeted node was successfully resected with the radioactive probe during TAD. In one patient, the seed was retrieved inferiorly in the axilla during surgery. There was no adverse event. In total, 50% (17/34) of patients had no residual metastases and were able to avoid ALND. Eight out of 17 patients who underwent ALND did not have any residual disease in their specimen. The mean cost of TAD was 25% superior to the mean cost of ALND (p = 0.02). However, the mean total cost of the hospital stay for TAD was 20% superior to the mean cost of ALND (p = 0.11). The mean cost of TAD was 4,322 Can$ (Canadian dollars), similar to the mean cost of both ALND and SLND performed during the same procedure (4,479 Can$). ConclusionsTAD was successful in 97% of patients. Despite increased procedural costs, with a lesser impact on total hospital stay costs, TAD was beneficial in 50% of patients. These patients avoided the unnecessary morbidity associated with ALND.
Background: The COVID-19 pandemic has been an unprecedented and potentially stressful event that inserted itself into the 2019-2020 Canadian medical curriculum. However, its impact on stress and subsequent professional pathways is not well understood. This study aims to assess the impact the COVID-19 pandemic on the mental well-being, training, and career choices of Canadian medical clerks within the first three months of the pandemic. It also aims to assess their use of university support systems and their appreciation of potential solutions to common academic stressors.Methods: An electronic survey composed of four sections: demographics, stressors experienced during the pandemic, World Health Organization (WHO) well-being index, and stress management and resources was distributed to Canadian clerks. Results: Clerks from 10 of the 17 Canadian medical faculties participated in this study (n=627). Forty-five percent of clerks reported higher levels of stress than usual; 22% reconsidered their residency choice; and 19% reconsidered medicine as a career. The factors that were most stressful among clerks were: the means of return to rotations; decreased opportunities to be productive in view of residency match; and taking the national licensing exam after the beginning of residency. The mean WHO well-being index was 14.8/25 4.5, indicating a poor level of well-being among a considerable proportion of students. Clerks who reconsidered their residency choice or medicine as a career had lower mean WHO well-being indices. Most clerks agreed with the following suggested solutions: training sessions on the clinical management of COVID-19 cases; being allowed to submit fewer reference letters when applying to residency; and having protected time to study for their licensing exam during residency. Overall, clerks were less concerned with being infected during their rotations than with the impact of the pandemic on their future career and residency match. Conclusion: The COVID-19 pandemic had a considerable impact on the medical curriculum and well-being of clerks. A number of student-identified solutions were proposed to reduce stress. The implementation of these solutions throughout the Canadian medical training system should be considered.
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