Objectives: We demonstrate a case report of the patient who suffered from advanced gastric cancer and was treated by means of surgery and HIPEC. Background: Gastric cancer is a therapeutic challenge in the European countries due to late diagnosis, advanced stages of the disease in time of diagnosis and early recurrence in cases where a radical surgery is possible. Method: The patient with an advanced gastric cancer (pT3N2M1 -peritoneal and ovarian metastases) was treated by means of radical surgery in combination with hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) and early postoperative intraperitoneal chemotherapy (EPIC). Surgical treatment was followed by a standard chemotherapy. Due to recurrence, there was the second look surgery one year later again with HIPEC procedure. Results: Patient survived 32 months after diagnosis and despite intraperitoneal recurrence she never developed clinically signifi cant ascites and she never suffered from intestinal obstruction. Conclusion: This case demonstrate a potential benefi t of new oncosurgical approach -radical surgery + HIPEC + EPIC in the treatment of gastric cancers (Tab. 2, Fig. 6, Graph 4, Ref. 18). Text in PDF www.elis.sk.
In Germany some 2 000 children and adolescent are diagnosed with cancer every year. Curing rates are increasing and therewith also the number of survivors is growing. Survivors frequently suffer from long-term effects of the disease and its treatment, but long-term follow-up care shows deficits. The Network for oncological advisory service (NOF) started in 11/2013, researching and building up a network of available support in Lower Saxony. A telephone hotline was installed in 01/2014 in order to advice survivors on their problems. At the same time, an interview study on survivors needs was conducted throughout Germany. In the first 2 years, the NOF gave advice to 79 patients. Whilst enquiries of medical or psychological nature were transferred to the cooperation partner, requests on psychosocial and social legal issues are being deled by the NOF due to lack of appropriate partners. The evaluation of 25 interviews shows key issues in long-term after-care: (1) transition from acute therapy to everyday life, (2) problems due to pediatric cancer and therapy, (3) patients perception of own disposition, (4) social reactions towards survivors, (5) structure of long-term follow-up care, (6) information flow. Many survivors suffer from long-term effects of cancer and treatment. The lack of available contact person and being in limbo between cured and simultaneously affected by the cancer treatment and chronic diseases is perceived as being problematic. This translates to various requirements on a patient-oriented long-term care, mainly in the psychosocial field.
Chloroacetanilide herbicides are widely used in the agricultural sector throughout the world. Because of their poor biodegradability, high water solubility, and long persistence, chloroacetanilide herbicides have a high potential to contaminate water, and conventional water treatment processes do not ensure sufficient removal. Therefore, heterogeneous photocatalysis using TiO2/UV-A was investigated for the degradation of alachlor, acetochlor, and metolachlor from water. Two commercially available TiO2 (P25 and AV-01) were used as photocatalysts. Different experimental setups were also tested. In addition, the toxicity of single herbicides and mixtures of their photocatalytic degradation products to the freshwater alga Chlorella kessleri was investigated via a growth inhibition test. The maximum removal efficiency for alachlor, acetochlor, and metolachlor was 97.5%, 93.1%, and 98.2%, respectively. No significant differences in the removal efficiency of chloroacetanilide herbicides were observed for the photocatalysts used. Although the concentrations of all herbicides during photocatalysis decreased, the toxicity of the resulting mixtures of degradation products increased or remained the same, indicating the formation of toxic degradation products.
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