Cancer-associated fibroblasts (CAFs) are generally associated with poor clinical outcome. CAFs support tumor growth in a variety of ways and can suppress antitumor immunity and response to immunotherapy. However, a precise understanding of CAF contributions to tumor growth and therapeutic response is lacking. Discrepancies in this field of study may stem from heterogeneity in composition and function of fibroblasts in the tumor microenvironment. Furthermore, it remains unclear whether CAFs directly interact with and suppress T cells. Here, mouse and human breast tumors were used to examine stromal cells expressing fibroblast activation protein (FAP), a surface marker for CAFs. Two discrete populations of FAP+ mesenchymal cells were identified on the basis of podoplanin (PDPN) expression: a FAP+PDPN+ population of CAFs and a FAP+PDPN⁻ population of cancer-associated pericytes (CAPs). Although both subsets expressed extracellular matrix molecules, the CAF transcriptome was enriched in genes associated with TGFβ signaling and fibrosis compared with CAPs. In addition, CAFs were enriched at the outer edge of the tumor, in close contact with T cells, whereas CAPs were localized around vessels. Finally, FAP+PDPN+ CAFs suppressed the proliferation of T cells in a nitric oxide-dependent manner whereas FAP+PDPN⁻ pericytes were not immunosuppressive. Collectively, these findings demonstrate that breast tumors contain multiple populations of FAP-expressing stromal cells of dichotomous function, phenotype, and location.

This case series should alert the physicians to the possibility of pyogenic sacroiliitis and the difference between paediatric and adult patients.

Previous research showed that in the individualistic culture, adults endorse the personal more than the general belief in a just world (PBJW vs. GBJW). Comparatively little is known about the prevalence character and adaptive functions of GBJW, especially in the collectivistic culture. We conducted three surveys among the Chinese adults and adolescents. We found that (1) Chinese adults and adolescents endorsed more GBJW than PBJW; (2) Adult survivors with high exposure to post‐earthquake trauma and adolescents in the poverty‐stricken area maintained high GBJW, with relatively lower PBJW. (3) GBJW predicted the psychological resilience in all the three samples independent of PBJW. The results imply that in contrast to populations from the individualistic culture, people from the collectivistic culture endorse a robust GBJW, which allows them to resiliently confront harsh realities. Copyright © 2010 John Wiley & Sons, Ltd.