The authors conclude that isoflurane differentially affects both neurogenesis and long-term neurocognitive function in P60 and P7 rats. Neurogenesis might mediate the long-term neurocognitive outcome after isoflurane at different ages.

Abstract-We have done a detailed petrologic study of the angrite, D'Orbigny, and geochemical study of it and Sahara 99555. D'Orbigny is an igneous-textured rock co m posed of Ca-rich olivine, Al-Tidiopside-hedenbergite, subcalcic kirschsteinite, two generations of hercynitic spinel and anorthite, with the mesostasis phases ulvospinel, Ca-phosphate, a silico-phosphate phase and Fe-sulfide. We report an unknown Fe-Ca-Al-Ti-silicate phase in the mesostasis not previously found in angrites. One hercynitic spinel is a large, rounded homogeneous grain of a different composition than the euhedral and zoned grains. We believe the former is a xenocryst, the first such described from angrites.The mafic phases are highly zoned; mg# of cores for olivine are -64, and for clinopyroxene -58, and both are zoned to Mg-free rims . The Ca content of olivine increases with decreasing mg#, until olivine with -2 0 mol% C a is overgrown by subcalcic kirschsteinite with about 30-35 mol% Ca. Detailed zoning sequences in olivine-subcalcic kirschsteinite and clinopyroxene show slight compositional reversals . There is no mineralogic control that can explain these reversals, and we believe they were likely caused by local additions of more primitive melt during cry sta llization of D'Orbigny. D'Orbigny is the most ferroan angrite with a bulk rock mg# of32. Compositionally, it is virtually identical to Sahara 99555; they are the first set of compositionally identical angrites. Comparison with the other angrites shows that there is no simple petrogenetic sequence, partial melting with or without fractional crystallization, that can explain the angrite suite. Angra dos Reis remains an anomalous angrite.Angrites show no evidence for the brecciation, shock, impact metamorphism, or thermal metamorphism that affected the howardite, eu crite, diogenite (HED) suite and ordinary chondrites. This suggests that the angrite parent body may have followed a fundamentally different evolutionary path than did these other parent bodies.

Lysenko 91,92 | Armin Macanović 93 | Parastoo Mahdavi 94 | Peter Manning 35 | Corrado Marcenò 13 | Vassiliy Martynenko 95 | Maurizio Mencuccini 96 | Vanessa Minden 97 | Jesper Erenskjold Moeslund 54 | Marco Moretti 98 | Jonas V. Müller 99 | Abstract Aims: Vegetation-plot records provide information on the presence and cover or abundance of plants co-occurring in the same community. Vegetation-plot data are spread across research groups, environmental agencies and biodiversity research centers and, thus, are rarely accessible at continental or global scales. Here we present the sPlot database, which collates vegetation plots worldwide to allow for the exploration of global patterns in taxonomic, functional and phylogenetic diversity at the plant community level.Results: sPlot version 2.1 contains records from 1,121,244 vegetation plots, which comprise 23,586,216 records of plant species and their relative cover or abundance in plots collected worldwide between 1885 and 2015. We complemented the information for each plot by retrieving climate and soil conditions and the biogeographic context (e.g., biomes) from external sources, and by calculating community-weighted means and variances of traits using gap-filled data from the global plant trait database TRY. Moreover, we created a phylogenetic tree for 50,167 out of the 54,519 species identified in the plots. We present the first maps of global patterns of community richness and community-weighted means of key traits. Conclusions: The availability of vegetation plot data in sPlot offers new avenues for vegetation analysis at the global scale. K E Y W O R D S biodiversity, community ecology, ecoinformatics, functional diversity, global scale, macroecology, phylogenetic diversity, plot database, sPlot, taxonomic diversity, vascular plant, vegetation relevé 166 |

Isoflurane-induced brain cell death may be partly caused by hypercarbia. The inconsistencies between cell death and neurocognitive outcome suggest that additional or alternative mechanisms may mediate anesthesia-induced long-term neurocognitive dysfunction.

Chan et al. report that treatment of tumor-bearing mice with low-dose metronomic chemotherapy prevents stromal secretion of ELR+ chemokines and induction of tumor-initiating cells usually observed with administration of drugs at maximum tolerated dose.