Clergy (N = 179) in the catchment areas of four hospitals in New York and Connecticut were surveyed about their pastoral care activities. Factor analysis revealed two separate sets of problems presented in pastoral counseling, with respect to clergy's ratings of their competence to address them. The first factor included grief, death and dying, anxiety, and marital problems, in descending order of frequency. The second factor consisted of depression, alcohol/drugs, domestic violence, severe mental illness, HIV/AIDS, and suicide. Clergy were significantly less confident of their ability to deal with Factor 2 problems, yet clergy rarely consulted with mental-health professionals about either type of problem. Less than half of the clergy had training in Clinical Pastoral Education, but those who did tended to feel they were more competent to deal with both types of problems. On average, clergy devoted 3.7 hours per week to visiting patients and nearly 55% said they were "definitely more likely" to refer a patient to a hospital with a pastoral care department.

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Each year, approximately 4300 children, adolescents and young adults (CAYA) are diagnosed with cancer. One-third of these patients present with metastatic disease, develop refractory disease or relapse. For these patients, the likelihood of survival remains grim and essentially unchanged in more than three decades. Precision Oncology for Young PeopLE (PROFYLE) is a pan-Canadian, interdisciplinary program that was built on the foundation of three major sequencing efforts in Vancouver (PedsPOG), Toronto (KiCS) and Montreal (TRICEPS) for children with hard-to-treat cancer. Since its inception in 2017, over 700 patients have had complete NGS of paired blood-tumor samples with a goal to not only develop a national precision oncology pipeline, but also to determine the frequency and spectrum of molecular targets for novel therapies and other clinically actionable findings. During this presentation, both the process as well as current findings will be presented and plans for the future will be outlined. Citation Format: David Malkin, Jason N. Berman, Jennifer A. Chan, Avram Denburg, Rebecca Deyell, David Eisenstadt, Conrad Fernandez, Stephanie Grover, Abha Gupta, Cynthia Hawkings, Meredith Irwin, Nada Jabado, Steven Jones, Daniel Morgenstern, Michael Moran, Rod Rasesekh, Adam Shlien, Daniel Sinnett, Poul Sorensen, Patrick Sullivan, Michael Taylor, Anita Villani, Jim Whitlock. PROFYLEing Cancer for KiCS: The Canadian Pediatric Precision Oncology Initiative [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr SY09-03.